NEGATIVE REGULATION OF IMMUNORECEPTOR SIGNALING

Immune cells are activated as a result of productive interactions between ligands and various receptors known as immunoreceptors. These receptors function by recruiting cytoplasmic protein tyrosine kinases, which trigger a unique phosphorylation signal leading to cell activation. In the recent past,...

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Bibliographic Details
Published in:Annual review of immunology 2002-01, Vol.20 (1), p.669-707
Main Authors: Veillette, André, Latour, Sylvain, Davidson, Dominique
Format: Article
Language:English
Subjects:
adaptor
Animals
B-Lymphocytes - immunology
Csk
Humans
inhibition
Intracellular Signaling Peptides and Proteins
ITIM
Models, Immunological
phosphatase
Protein Tyrosine Phosphatase, Non-Receptor Type 6
Protein Tyrosine Phosphatases - metabolism
Protein-Tyrosine Kinases - metabolism
Receptors, Immunologic - metabolism
Signal Transduction
src-Family Kinases - metabolism
T-Lymphocytes - immunology
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Summary:Immune cells are activated as a result of productive interactions between ligands and various receptors known as immunoreceptors. These receptors function by recruiting cytoplasmic protein tyrosine kinases, which trigger a unique phosphorylation signal leading to cell activation. In the recent past, there has been increasing interest in elucidating the processes involved in the negative regulation of immunoreceptor-mediated signal transduction. Evidence is accumulating that immunoreceptor signaling is inhibited by complex and highly regulated mechanisms that involve receptors, protein tyrosine kinases, protein tyrosine phosphatases, lipid phosphatases, ubiquitin ligases, and inhibitory adaptor molecules. Genetic evidence indicates that this inhibitory machinery is crucial for normal immune cell homeostasis.
ISSN:0732-0582
1545-3278
DOI:10.1146/annurev.immunol.20.081501.130710