Genomic diversity of human immunodeficiency virus type-1 in India

Surveillance of HIV-1 subtypes has important implications for the development of candidate vaccine and understanding the possible differences in the transmission and natural history of different subtypes. In this study, HIV-1 subtypes were determined for homologies in the C2-V3-V5 region by heterodu...

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Bibliographic Details
Published in:International journal of STD & AIDS 2002-02, Vol.13 (2), p.115-118
Main Authors: SAHNI, A. K, PRASAD, V. V. S. P, SETH, P
Format: Article
Language:English
Subjects:
AIDS/HIV
Biological and medical sciences
Female
Genetic Variation
Genome, Viral
Heteroduplex Analysis
HIV Envelope Protein gp120 - genetics
HIV Infections - epidemiology
HIV Infections - virology
HIV-1 - classification
HIV-1 - genetics
Human immunodeficiency virus 1
Human viral diseases
Humans
India - epidemiology
Infectious diseases
Male
Medical sciences
Molecular Epidemiology
Peptide Fragments - genetics
Tropical medicine
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:Surveillance of HIV-1 subtypes has important implications for the development of candidate vaccine and understanding the possible differences in the transmission and natural history of different subtypes. In this study, HIV-1 subtypes were determined for homologies in the C2-V3-V5 region by heteroduplex mobility assay (HMA) in HIV-1 seropositive patients referred to the National HIV/AIDS Reference Centre, All India Institute of Medical Sciences in New Delhi, India. Of the 125 samples analysed, 98 (78.4%) were HIV-1 subtype C, 11 (8.8%) were subtype B′, 3 (2.4%) were subtype A and 2 (1.6%) were subtype E. In 11 samples, subtype determination was not clear-cut. It is possible that these individuals may be infected with recombinant strains of HIV-1. These findings may have significant implications for the designing and testing of effective HIV-1 vaccine candidate in India.
ISSN:0956-4624
1758-1052
DOI:10.1258/0956462021924749