Losartan treatment and left ventricular filling during volume loading in patients with dilated cardiomyopathy

Background Patients with mild heart failure show a reduction in preload reserve mechanism during volume expansion. At this time, the effects of volume expansion on left ventricular (LV) diastolic filling in this subset of patients have not been well characterized. Methods We evaluated the effects of...

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Bibliographic Details
Published in:The American heart journal 2002-03, Vol.143 (3), p.433-440
Main Authors: Spinelli, Letizia, Petretta, Mario, Vicario, Maria L.E., Schiavone, Daniela, De Santis, Valerio, Bonaduce, Domenico, Condorelli, Mario
Format: Article
Language:English
Subjects:
Adult
Aldosterone - blood
Analysis of Variance
Anti-Arrhythmia Agents - therapeutic use
Antihypertensive Agents - therapeutic use
Biological and medical sciences
Blood Flow Velocity
Cardiomyopathy, Dilated - blood
Cardiomyopathy, Dilated - drug therapy
Cardiomyopathy, Dilated - physiopathology
Cardiotonic agents
Cardiovascular system
Case-Control Studies
Disease
Drug therapy
Echocardiography
Female
Flow velocity
Heart failure
Heart rate
Humans
Losartan - therapeutic use
Male
Medical sciences
Middle Aged
Mitral Valve - physiopathology
Myocardial Contraction
Patients
Pharmacology. Drug treatments
Potassium
Pulmonary Circulation
Renin - blood
Studies
Ventricular Function, Left
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Summary:Background Patients with mild heart failure show a reduction in preload reserve mechanism during volume expansion. At this time, the effects of volume expansion on left ventricular (LV) diastolic filling in this subset of patients have not been well characterized. Methods We evaluated the effects of acute volume loading on Doppler parameters of LV filling in 10 healthy control subjects and in 12 patients with idiopathic dilated cardiomyopathy (DCM). In patients with DCM, the effects of losartan on diastolic adaptation to volume load were also investigated. Results During volume loading, the healthy control subjects showed a decrease in isovolumic relaxation time (F = 5.3, P
ISSN:0002-8703
1097-6744
DOI:10.1067/mhj.2002.119893