Determination of ampicillin and amoxycillin by flow injection chemiluminescence method based on their enhancing effects on the luminol-periodate reaction

In this work, a new flow injection chemiluminescence method is described for the determination of ampicillin and amoxycillin. The method is based on the strong enhancing effects of these antibiotics on the luminol–periodate reaction. The present method allows the measurements of ampicillin in the ra...

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Bibliographic Details
Published in:Luminescence (Chichester, England) England), 2003-11, Vol.18 (6), p.313-317
Main Authors: Li, Yinhuan, Tang, Yuhai, Yao, Hong, Fu, Junmei
Format: Article
Language:English
Subjects:
Amoxicillin - analysis
amoxycillin
ampicillin
Ampicillin - analysis
Anti-Bacterial Agents - analysis
chemiluminescence
flow injection
Flow Injection Analysis - methods
Indicators and Reagents
Luminescent Measurements
Luminol - chemistry
Periodic Acid - chemistry
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Summary:In this work, a new flow injection chemiluminescence method is described for the determination of ampicillin and amoxycillin. The method is based on the strong enhancing effects of these antibiotics on the luminol–periodate reaction. The present method allows the measurements of ampicillin in the range 0.02–1.0 mg/L range and amoxycillin in the range 0.1–10.0 mg/L range with the relative standard deviations within 0.8–2.0%. The sampling frequency was calculated about 90/h. The method was successfully applied to the determination of ampicillin and amoxycillin in pharmaceutical preparations. A brief discussion on the possible chemiluminescence reaction mechanism is presented. Copyright © 2003 John Wiley & Sons, Ltd.
ISSN:1522-7235
1522-7243
DOI:10.1002/bio.741