Coenzyme Q10, antioxidant status and ApoE isoforms

The aim of this study was to inquire the antioxidant status in plasma and lipoproteins isolated from normal subjects possessing different ApoE genotypes. For this purpose we investigated blood samples from 106 healthy blood donors: the distribution of ApoE alleles (E2/E2 = 0.9%, E2/E3 = 10.4%, E2/E4...

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Bibliographic Details
Published in:BioFactors (Oxford) 2003, Vol.18 (1-4), p.299-305
Main Authors: Battino, M., Giunta, S., Galeazzi, L., Galeazzi, R., Mosca, F., Santolini, C., Principi, F., Ferretti, G., Bacchetti, T., Bencivenga, R., Piani, M., Riganello, G., Littarru, G. P.
Format: Article
Language:English
Subjects:
Alleles
Antioxidants - analysis
Apolipoprotein E2
Apolipoprotein E3
Apolipoprotein E4
Apolipoproteins E - blood
Apolipoproteins E - genetics
Aryldialkylphosphatase - blood
Blood Donors
Cholesterol Esters - blood
cholesteryl-esters hydroperoxide
Coenzymes
Genotype
HDL
Humans
Hydrogen Peroxide - blood
LDL
Lipoproteins, HDL - blood
Lipoproteins, LDL - blood
paraoxonase
Ubiquinone - analogs & derivatives
Ubiquinone - blood
Vitamin E
Vitamin E - blood
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Summary:The aim of this study was to inquire the antioxidant status in plasma and lipoproteins isolated from normal subjects possessing different ApoE genotypes. For this purpose we investigated blood samples from 106 healthy blood donors: the distribution of ApoE alleles (E2/E2 = 0.9%, E2/E3 = 10.4%, E2/E4 = 2.8%, E3/E3 = 71.7%, E3/E4 = 12.3% and E4/E4 1.9% with 1, 11, 3, 76, 13, and 2 subjects respectively for each genotype) was in agreement with previous data. Almost no differences were found in the concentrations of both coenzyme Q10 (CoQ10) and vitamin E for the different genotypes. Concentration of CoQ10 in isolated lipoproteins was also similar, in the different genotypes, when referred to cholesterol; CoQ10 in LDL was higher for the E3/E3 subjects when referred to protein. Neither CoQ10 nor vitamin E correlated with paraoxonase (PON) activity or cholesteryl‐ester hydroperoxides (CHP). Furthermore, there was no correlation between the same lipophilic antioxidants and CHP levels. The only E2 homozygous subject found had high levels of PON and low levels of CHP; the two E4/E4 subjects had low PON activity together with low levels of CHP.
ISSN:0951-6433
1872-8081
DOI:10.1002/biof.5520180234