PET measures of pre- and post-synaptic cardiac beta adrenergic function

Positron Emission Tomography was used to measure global and regional cardiac β-adrenergic function in 19 normal subjects and 9 congestive heart failure patients. [ 11C]-meta-hydroxyephedrine was used to image norepinephrine transporter function as an indicator of pre-synaptic function and [ 11C]-CGP...

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Bibliographic Details
Published in:Nuclear medicine and biology 2003-11, Vol.30 (8), p.795-803
Main Authors: Link, Jeanne M, Stratton, John R, Levy, Wayne, Poole, Jeanne E, Shoner, Steven C, Stuetzle, Werner, Caldwell, James H
Format: Article
Language:English
Subjects:
[ 11C]-CGP12177
[ 11C]-mHED
Aged
Aged, 80 and over
Autonomic Nervous System Diseases - diagnostic imaging
Autonomic Nervous System Diseases - metabolism
Beta adrenergic
Biological and medical sciences
Cardiac
Female
Heart - diagnostic imaging
Heart - innervation
Heart Failure - diagnostic imaging
Heart Failure - metabolism
Humans
Image Interpretation, Computer-Assisted - methods
Male
Medical sciences
Middle Aged
PET
Pilot Projects
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Receptors, Adrenergic, beta - metabolism
Reproducibility of Results
Sensitivity and Specificity
Sympathetic function
Synapses - diagnostic imaging
Synapses - metabolism
Technology. Biomaterials. Equipments. Material. Instrumentation
Tissue Distribution
Tomography, Emission-Computed - methods
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Summary:Positron Emission Tomography was used to measure global and regional cardiac β-adrenergic function in 19 normal subjects and 9 congestive heart failure patients. [ 11C]-meta-hydroxyephedrine was used to image norepinephrine transporter function as an indicator of pre-synaptic function and [ 11C]-CGP12177 was used to measure cell surface β-receptor density as an indicator of post-synaptic function. Pre-synaptic, but not post-synaptic, function was significantly different between normals and CHF patients. Pre-synaptic function was well matched to post-synaptic function in the normal hearts but significantly different and poorly matched in the CHF patients studied. This imaging technique can help us understand regional sympathetic function in cardiac disease.
ISSN:0969-8051
1872-9614
DOI:10.1016/j.nucmedbio.2003.09.002