Emerging array-based technologies in proteomics

Microarray format is the method of choice for high-throughput hybridization of nucleic acids. Lately, microarray strategy has been applied to broad studies of interactions of proteins with other molecules. The diversity of these interactions and variations of the properties of proteins present new c...

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Bibliographic Details
Published in:Current Opinion in Chemical Biology 2002-02, Vol.6 (1), p.70-75
Main Authors: Mirzabekov, Andrei, Kolchinsky, Alexander
Format: Article
Language:English
Subjects:
Animals
Biotechnology - methods
DNA microarrays
DNA-Binding Proteins - analysis
DNA-protein interactions
Genome
Humans
Immunoassay - methods
Microarrays
Microchemistry
microchips
Miniaturization
Oligonucleotide Array Sequence Analysis
Protein Binding
protein-ligand binding
protein-protein interactions
proteins
Proteome - analysis
proteomics
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Summary:Microarray format is the method of choice for high-throughput hybridization of nucleic acids. Lately, microarray strategy has been applied to broad studies of interactions of proteins with other molecules. The diversity of these interactions and variations of the properties of proteins present new challenges to microchip technology. Significant achievements have been reported. In particular, three-dimensional (gel-based) chips can be manufactured with limited resources and offer flexibility, capacity, homogeneous solvent environment and the ability to record processes in real time and in variable conditions. Microarrays are the method of choice for high-throughput hybridization of nucleic acids. Lately, the technology has been applied to studies of proteins with other molecules.
ISSN:1367-5931
1879-0402
DOI:10.1016/S1367-5931(01)00286-1