Quantitative coronary angiography in regression trials: a review of methodologic considerations, endpoint selection, and limitations

Several quantitative angiographic methods (visual assessment, digital hand-held calipers, and automated edge detection) have been successfully used to assess coronary atherosclerosis regression. These methods are applicable for (1) continuous measures of disease progression and regression, including...

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Bibliographic Details
Published in:The American journal of cardiology 2002-02, Vol.89 (4), p.4-9
Main Authors: Lansky, Alexandra J, Desai, Kartik, Leon, Martin B
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiovascular disease
Cardiovascular system
Clinical trials
Coronary Angiography
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - physiopathology
Coronary Artery Disease - therapy
Disease Progression
Endpoint Determination
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical procedures
Medical sciences
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Remission Induction
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Summary:Several quantitative angiographic methods (visual assessment, digital hand-held calipers, and automated edge detection) have been successfully used to assess coronary atherosclerosis regression. These methods are applicable for (1) continuous measures of disease progression and regression, including patient-based, segment-based, and lesion-based analyses; and (2) categorical assessment of disease progression and regression (the use of a predefined threshold to categorize the course of disease). Angiographic methods and criteria for assessing disease progression each have distinct advantages and disadvantages, which accounts for the methodologic diversity seen in clinical trials.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(01)02326-8