Ventilatory response to exercise improves risk stratification in patients with chronic heart failure and intermediate functional capacity

Background Peak oxygen consumption (VO2) has an important prognostic role in chronic heart failure (CHF), but its discriminatory power is limited in patients with intermediate exercise capacity (peak VO2 between 10-18 mL/kg/min). Thus, supplementary exertional indexes are greatly needed. Methods Six...

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Bibliographic Details
Published in:The American heart journal 2002-03, Vol.143 (3), p.418-426
Main Authors: Corrà, Ugo, Mezzani, Alessandro, Bosimini, Enzo, Scapellato, Francesco, Imparato, Alessandro, Giannuzzi, Pantaleo
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carbon dioxide
Carbon Dioxide - metabolism
Cardiology
Cardiology. Vascular system
Death, Sudden
Echocardiography
Exercise - physiology
Exercise Test
Female
Flow velocity
Follow-Up Studies
Heart
Heart attacks
Heart failure
Heart Failure - mortality
Heart Failure - physiopathology
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Humans
Male
Medical sciences
Middle Aged
Mortality
Multivariate Analysis
Oxygen Consumption - physiology
Population
Prognosis
Pulmonary Gas Exchange
Regression Analysis
Respiration
Stroke Volume
Transplants & implants
Variables
Ventilation
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Summary:Background Peak oxygen consumption (VO2) has an important prognostic role in chronic heart failure (CHF), but its discriminatory power is limited in patients with intermediate exercise capacity (peak VO2 between 10-18 mL/kg/min). Thus, supplementary exertional indexes are greatly needed. Methods Six hundred patients with CHF with left ventricular ejection fraction (LVEF) ≤40% who performed a symptom-limited cardiopulmonary exercise testing were screened and followed up for 780 ± 450 days. Results Eighty-seven patients had major cardiac events (77 cardiac deaths and 10 urgent heart transplantations). Multivariate analysis revealed the rate of increase of minute ventilation per unit of increase of carbon dioxide production (VE/VCO2 slope) (χ2, 79.3, P
ISSN:0002-8703
1097-6744
DOI:10.1067/mhj.2002.120772