Percutaneous bioprosthetic venous valve: A long-term study in sheep

A long-term evaluation of a new percutaneously placed bioprosthetic, bicuspid venous valve (BVV) consisting of a square stent and small intestinal submucosa (SIS) covering was performed in 12 sheep. Of 26 BVVs placed into the jugular veins, 25 exhibited good valve function on immediate venography an...

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Bibliographic Details
Published in:Journal of vascular surgery 2002-03, Vol.35 (3), p.598-602
Main Authors: Pavcnik, Dusan, Uchida, Barry T., Timmermans, Hans A., Corless, Christopher L., O'Hara, Michael, Toyota, Naoyuki, Moneta, Gregory L., Keller, Frederick S., Rösch, Josef
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Bioprosthesis
Blood Vessel Prosthesis Implantation - instrumentation
Equipment Safety
Female
Follow-Up Studies
Jugular Veins - diagnostic imaging
Jugular Veins - surgery
Medical sciences
Models, Animal
Phlebography
Prosthesis Design
Sheep
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
Surgical Instruments
Time
Time Factors
Treatment Outcome
Vascular Patency - physiology
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Summary:A long-term evaluation of a new percutaneously placed bioprosthetic, bicuspid venous valve (BVV) consisting of a square stent and small intestinal submucosa (SIS) covering was performed in 12 sheep. Of 26 BVVs placed into the jugular veins, 25 exhibited good valve function on immediate venography and 22 on venograms obtained before the sheep were killed. Gross and histologic examination results demonstrated incorporation of remodeled and endothelialized SIS BVVs into the vein wall. Slight to moderate leaflet thickening was found mostly at their bases. Percutaneously placed SIS BVV is a promising one-way, competent valve that resists venous back-pressure while allowing forward flow.
ISSN:0741-5214
1097-6809
DOI:10.1067/mva.2002.118825