Viral and Cellular Specificities of Caprine Arthritis Encephalitis Virus Vif Protein

The caprine arthritis encephalitis virus (CAEV) Vif protein is necessary for a productive infection of susceptible goat cells. The vif gene is conserved among all primate and most nonprimate lentiviruses. However, previous reports demonstrated that, in their respective host cells, primate Vif delete...

Full description

Saved in:
Bibliographic Details
Published in:Virology (New York, N.Y.) N.Y.), 2002-01, Vol.292 (1), p.156-161
Main Authors: Seroude, Virginie, Audoly, Gilles, Gluschankof, Pablo, Suzan, Marie
Format: Article
Language:English
Subjects:
Animals
Arthritis-Encephalitis Virus, Caprine - metabolism
Arthritis-Encephalitis Virus, Caprine - pathogenicity
CAEV
Caprine arthritis encephalitis virus
Cell Line
cell specificity
Gag
Gene Deletion
Gene Products, gag - metabolism
Gene Products, vif - genetics
Gene Products, vif - metabolism
Goats
HIV-1
HIV-1 - genetics
HIV-1 - pathogenicity
Humans
interaction
Lentivirus Infections - virology
lentiviruses
Leukemia Virus, Murine - genetics
Leukemia Virus, Murine - pathogenicity
Mice
MLV
Protein Precursors - metabolism
retroviruses
Vif
vif Gene Products, Human Immunodeficiency Virus
Vif protein
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The caprine arthritis encephalitis virus (CAEV) Vif protein is necessary for a productive infection of susceptible goat cells. The vif gene is conserved among all primate and most nonprimate lentiviruses. However, previous reports demonstrated that, in their respective host cells, primate Vif deleted lentiviruses could not be complemented by nonprimate Vif proteins, suggesting that species-specific restrictions between Vif and the virus-producing cells may modulate the Vif function on viral infectivity. Here we bring further support to this hypothesis since we show that CAEV Vif, when expressed in goat cells, is able to increase the infectivity of Vif deleted human immunodeficiency type-1 virus and of murine leukemia virus. Moreover, we demonstrate in vitro interactions between different Vif proteins and NC domains of heterologous Gag precursors, supporting the notion that species specificity of lentiviral infection is not due to molecular interactions between Vif and viral components.
ISSN:0042-6822
1096-0341
DOI:10.1006/viro.2001.1269