Follistatin Regulates Bone Morphogenetic Protein-7 (BMP-7) Activity to Stimulate Embryonic Muscle Growth

Bone morphogenetic proteins (BMPs) can either promote growth of embryonic muscle by expanding the Pax-3-expressing muscle precursor population or restrict its development by inducing apoptosis. Follistatin, a proposed BMP antagonist, is expressed in embryonic muscle. Deficiency in Follistatin result...

Full description

Saved in:
Bibliographic Details
Published in:Developmental biology 2002-03, Vol.243 (1), p.115-127
Main Authors: Amthor, Helge, Christ, Bodo, Rashid-Doubell, Fiza, Kemp, C.Fred, Lang, Emily, Patel, Ketan
Format: Article
Language:English
Subjects:
Activins - physiology
Animals
Biacore
BMP
Bone Morphogenetic Protein 2
Bone Morphogenetic Protein 7
Bone Morphogenetic Proteins - physiology
Chick Embryo
DNA-Binding Proteins - physiology
embryo
Embryo, Nonmammalian - physiology
Extremities - embryology
Extremities - physiology
Follistatin
Gene Expression Regulation, Developmental - physiology
Morphogenesis - physiology
muscle development
Muscle, Skeletal - embryology
Muscle, Skeletal - physiology
MyoD
Noggin
Paired Box Transcription Factors
Pax-3
PAX3 Transcription Factor
Signal Transduction
Transcription Factors - physiology
Transforming Growth Factor beta
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bone morphogenetic proteins (BMPs) can either promote growth of embryonic muscle by expanding the Pax-3-expressing muscle precursor population or restrict its development by inducing apoptosis. Follistatin, a proposed BMP antagonist, is expressed in embryonic muscle. Deficiency in Follistatin results in muscle defects and postnatal asphyxia. Here, we report that during chick limb development Follistatin enhances BMP-7 action to induce muscle growth but prevents the ability of BMP-7 to induce apoptosis and muscle loss. Follistatin, unlike another BMP-binding protein, Noggin, promotes Pax-3 expression and transiently delays muscle differentiation and thus exerts proliferative signalling during muscle development. We provide data which show that Follistatin binds BMP-7 and BMP-2 at low affinities and that the binding is reversible. These data suggest that Follistatin acts to present BMPs to myogenic cells at a concentration that permits stimulation of embryonic muscle growth.
ISSN:0012-1606
1095-564X
DOI:10.1006/dbio.2001.0555