Antigenemia at 10 years after diethylcarbamazine treatment of asymptomatic microfilaraemic individuals: marginal conversion to infection‐free state

Summary A group of asymptomatic microfilaraemic individuals (n = 44, 29 males, 15 females) living in a Wuchereria bancrofti endemic region of Orissa, India, was treated with a standard regimen of diethylcarbamazine (12 days, 6 mg/kg) in 1990. The incidence of microfilaraemia and antigenemia (Og4C3)...

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Bibliographic Details
Published in:Parasite immunology 2002-02, Vol.24 (2), p.109-111
Main Authors: Beuria, M. K., Bal, M. S., Mandal, N. N., Das, M. K.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Animals
antigenemia
Antigens, Helminth - blood
chemotherapy
diethylcarbamazine
Diethylcarbamazine - therapeutic use
Female
filariasis
Filariasis - diagnosis
Filariasis - drug therapy
Filariasis - epidemiology
Filariasis - parasitology
Filaricides - therapeutic use
Follow-Up Studies
Humans
India
Male
microfilaremia
Microfilariae - isolation & purification
Middle Aged
Og4C3
Patients
Wuchereria bancrofti
Wuchereria bancrofti - immunology
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Summary:Summary A group of asymptomatic microfilaraemic individuals (n = 44, 29 males, 15 females) living in a Wuchereria bancrofti endemic region of Orissa, India, was treated with a standard regimen of diethylcarbamazine (12 days, 6 mg/kg) in 1990. The incidence of microfilaraemia and antigenemia (Og4C3) was determined after a gap of 10 years in 2000. Nineteen individuals reacquired microfilariae (43·2%, 11 males, eight females), five males developed hydrocele, two females became acute filarial patients and 18 subjects (13 males, five females) were asymptomatic amicrofilaraemics. Filarial antigen was detected in 36 individuals (81·2%, 27 male, nine female) comprising microfilaraemics, amicrofilaraemics and diseased. Only eight individuals (18·2%, two males, six females) remained antigen free.
ISSN:0141-9838
1365-3024
DOI:10.1046/j.0141-9838.2001.00439.x