Stage specificity of Plasmodium falciparum telomerase and its inhibition by berberine

Telomerase activity in synchronized Plasmodium falciparum during its erythrocytic cycle was examined using the TRAP assay. Telomerase activity was detected at all stages of the parasite intraerythrocyte development, with higher activity in trophozoite and schizont stages compared with ring form. Ber...

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Bibliographic Details
Published in:Parasitology international 2002-03, Vol.51 (1), p.99-103
Main Authors: Sriwilaijareon, N, Petmitr, S, Mutirangura, A, Ponglikitmongkol, M, Wilairat, P
Format: Article
Language:English
Subjects:
Animals
Antimalarial
Berberine
Berberine - pharmacology
Erythrocytes - parasitology
Malaria, Falciparum - parasitology
Plasmodium falciparum
Plasmodium falciparum - enzymology
Plasmodium falciparum - growth & development
Telomerase
Telomerase - antagonists & inhibitors
Telomerase - metabolism
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Summary:Telomerase activity in synchronized Plasmodium falciparum during its erythrocytic cycle was examined using the TRAP assay. Telomerase activity was detected at all stages of the parasite intraerythrocyte development, with higher activity in trophozoite and schizont stages compared with ring form. Berberine, extracted from Arcangelisia flava (L.) Merr., inhibited telomerase activity in a dose-dependent manner over a range of 30–300 μM, indicating that P. falciparum telomerase might be a potential target for future malaria chemotherapy.
ISSN:1383-5769
1873-0329
DOI:10.1016/S1383-5769(01)00092-7