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Stage specificity of Plasmodium falciparum telomerase and its inhibition by berberine
Telomerase activity in synchronized Plasmodium falciparum during its erythrocytic cycle was examined using the TRAP assay. Telomerase activity was detected at all stages of the parasite intraerythrocyte development, with higher activity in trophozoite and schizont stages compared with ring form. Ber...
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Published in: | Parasitology international 2002-03, Vol.51 (1), p.99-103 |
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container_title | Parasitology international |
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creator | Sriwilaijareon, N Petmitr, S Mutirangura, A Ponglikitmongkol, M Wilairat, P |
description | Telomerase activity in synchronized
Plasmodium falciparum during its erythrocytic cycle was examined using the TRAP assay. Telomerase activity was detected at all stages of the parasite intraerythrocyte development, with higher activity in trophozoite and schizont stages compared with ring form. Berberine, extracted from
Arcangelisia flava (L.) Merr., inhibited telomerase activity in a dose-dependent manner over a range of 30–300 μM, indicating that
P. falciparum telomerase might be a potential target for future malaria chemotherapy. |
doi_str_mv | 10.1016/S1383-5769(01)00092-7 |
format | article |
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Plasmodium falciparum during its erythrocytic cycle was examined using the TRAP assay. Telomerase activity was detected at all stages of the parasite intraerythrocyte development, with higher activity in trophozoite and schizont stages compared with ring form. Berberine, extracted from
Arcangelisia flava (L.) Merr., inhibited telomerase activity in a dose-dependent manner over a range of 30–300 μM, indicating that
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Plasmodium falciparum during its erythrocytic cycle was examined using the TRAP assay. Telomerase activity was detected at all stages of the parasite intraerythrocyte development, with higher activity in trophozoite and schizont stages compared with ring form. Berberine, extracted from
Arcangelisia flava (L.) Merr., inhibited telomerase activity in a dose-dependent manner over a range of 30–300 μM, indicating that
P. falciparum telomerase might be a potential target for future malaria chemotherapy.</description><subject>Animals</subject><subject>Antimalarial</subject><subject>Berberine</subject><subject>Berberine - pharmacology</subject><subject>Erythrocytes - parasitology</subject><subject>Malaria, Falciparum - parasitology</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - enzymology</subject><subject>Plasmodium falciparum - growth & development</subject><subject>Telomerase</subject><subject>Telomerase - antagonists & inhibitors</subject><subject>Telomerase - metabolism</subject><issn>1383-5769</issn><issn>1873-0329</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqFkFtLJDEQRoOseP8JK3la9KHdVNLdST-JDN5AUJj1OaTTld1a-jImPcL8e3su4qNQUFVwqj44jP0EcQUCyt9zUEZlhS6rCwGXQohKZnqPHYHRKhNKVj-m-RM5ZMcp_RcCCq3hgB0CGCOkkkfsdT66v8jTAj0F8jSu-BD4S-tSNzS07HhwraeFi9M4Yjt0GF1C7vqG05g49f-oppGGntcrXmOcino8ZfvTXcKzXT9hr3e3f2YP2dPz_ePs5inzRanGLEfZyFqqArxSwdeqNF5qGYomQAhmvbjgZK5zbSqjaymm5hsMMlfS516dsF_bv4s4vC0xjbaj5LFtXY_DMlkNeVUp0N-CYJQuCygmsNiCPg4pRQx2EalzcWVB2LV4uxFv11atALsRb9cB57uAZd1h83W1Mz0B11sAJx_vhNEmT9h7bCiiH20z0DcRH6X9kyk</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Sriwilaijareon, N</creator><creator>Petmitr, S</creator><creator>Mutirangura, A</creator><creator>Ponglikitmongkol, M</creator><creator>Wilairat, P</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Stage specificity of Plasmodium falciparum telomerase and its inhibition by berberine</title><author>Sriwilaijareon, N ; Petmitr, S ; Mutirangura, A ; Ponglikitmongkol, M ; Wilairat, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c563t-4e2d2b2351c33fcb368c272f5df1ff88c27afa247478987b20898cdef2432c4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Antimalarial</topic><topic>Berberine</topic><topic>Berberine - pharmacology</topic><topic>Erythrocytes - parasitology</topic><topic>Malaria, Falciparum - parasitology</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium falciparum - enzymology</topic><topic>Plasmodium falciparum - growth & development</topic><topic>Telomerase</topic><topic>Telomerase - antagonists & inhibitors</topic><topic>Telomerase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sriwilaijareon, N</creatorcontrib><creatorcontrib>Petmitr, S</creatorcontrib><creatorcontrib>Mutirangura, A</creatorcontrib><creatorcontrib>Ponglikitmongkol, M</creatorcontrib><creatorcontrib>Wilairat, P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Parasitology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sriwilaijareon, N</au><au>Petmitr, S</au><au>Mutirangura, A</au><au>Ponglikitmongkol, M</au><au>Wilairat, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stage specificity of Plasmodium falciparum telomerase and its inhibition by berberine</atitle><jtitle>Parasitology international</jtitle><addtitle>Parasitol Int</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>51</volume><issue>1</issue><spage>99</spage><epage>103</epage><pages>99-103</pages><issn>1383-5769</issn><eissn>1873-0329</eissn><abstract>Telomerase activity in synchronized
Plasmodium falciparum during its erythrocytic cycle was examined using the TRAP assay. Telomerase activity was detected at all stages of the parasite intraerythrocyte development, with higher activity in trophozoite and schizont stages compared with ring form. Berberine, extracted from
Arcangelisia flava (L.) Merr., inhibited telomerase activity in a dose-dependent manner over a range of 30–300 μM, indicating that
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source | ScienceDirect Freedom Collection |
subjects | Animals Antimalarial Berberine Berberine - pharmacology Erythrocytes - parasitology Malaria, Falciparum - parasitology Plasmodium falciparum Plasmodium falciparum - enzymology Plasmodium falciparum - growth & development Telomerase Telomerase - antagonists & inhibitors Telomerase - metabolism |
title | Stage specificity of Plasmodium falciparum telomerase and its inhibition by berberine |
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