HLA-G and lymphoproliferative disorders

The immunomodulatory properties of the HLA-G molecule explain its relevance in malignancies. Our investigations in lymphoproliferative disorders show (i) a frequent and variable distribution of alternatively spliced HLA-G mRNA isoforms, (ii) a rare cell surface expression in diffuse large cell lymph...

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Bibliographic Details
Published in:Seminars in cancer biology 2003-10, Vol.13 (5), p.379-385
Main Authors: Amiot, Laurence, Friec, Gaëlle Le, Sebti, Yasmine, Drénou, Bernard, Pangault, Céline, Guilloux, Valérie, Leleu, Xavier, Bernard, Marc, Facon, Thierry, Fauchet, Renée
Format: Article
Language:English
Subjects:
Cell Division
ELISA
Enzyme-Linked Immunosorbent Assay
Exons
Flow Cytometry
Histocompatibility Antigens Class I - blood
Histocompatibility Antigens Class I - immunology
Histocompatibility Antigens Class I - physiology
HLA Antigens - blood
HLA Antigens - immunology
HLA Antigens - physiology
HLA-G
HLA-G Antigens
Humans
Lymphoma
Lymphoproliferative Disorders - immunology
Lymphoproliferative Disorders - metabolism
Multiple myeloma
Multiple Myeloma - immunology
Protein Isoforms
RNA, Messenger - metabolism
Transcription
Transcription, Genetic
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Summary:The immunomodulatory properties of the HLA-G molecule explain its relevance in malignancies. Our investigations in lymphoproliferative disorders show (i) a frequent and variable distribution of alternatively spliced HLA-G mRNA isoforms, (ii) a rare cell surface expression in diffuse large cell lymphomas with HLA class I loss in half of cases, and (iii) an increased serum level of sHLA-G in half of cases. The potential role of the microenvironment and/or tumoral process in HLA-G expression is discussed in the light of these data. HLA-G rather through its soluble isoform might provide a new way of immune evasion for lymphoid proliferations.
ISSN:1044-579X
1096-3650
DOI:10.1016/S1044-579X(03)00029-4