Renal Resistance Index and Progression of Renal Disease

The progression of renal disease depends on various clinical parameters such as hypertension and proteinuria. We recently showed that an increased renal resistance index measured by duplex ultrasound is associated with a poor prognosis in patients with renal artery stenosis. We now prospectively tes...

Full description

Saved in:
Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2002-02, Vol.39 (2, Part 2 Suppl), p.699-703
Main Authors: Radermacher, Jörg, Ellis, Sebastian, Haller, Hermann
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Disease Progression
Humans
Kidney Diseases - diagnostic imaging
Kidney Diseases - pathology
Kidney Diseases - physiopathology
Kidney Function Tests
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Renovascular diseases
Ultrasonography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c5371-ef4da8414f0c8bc61f8dda91f30d0fded659ed6d93b0a7d4a6591d4cdc1202033
cites cdi_FETCH-LOGICAL-c5371-ef4da8414f0c8bc61f8dda91f30d0fded659ed6d93b0a7d4a6591d4cdc1202033
container_end_page 703
container_issue 2, Part 2 Suppl
container_start_page 699
container_title Hypertension (Dallas, Tex. 1979)
container_volume 39
creator Radermacher, Jörg
Ellis, Sebastian
Haller, Hermann
description The progression of renal disease depends on various clinical parameters such as hypertension and proteinuria. We recently showed that an increased renal resistance index measured by duplex ultrasound is associated with a poor prognosis in patients with renal artery stenosis. We now prospectively tested the hypothesis that a high renal resistance index (≥80) predicts progression of renal disease in patients without renal artery stenosis. In 162 patients newly diagnosed with renal disease, the resistance index (1−[enddiastolic velocity/maximum systolic velocity]*100) was measured in segmental arteries of both kidneys. Creatinine clearance was measured at baseline, at 3, 6, and 12 months, and then at yearly intervals thereafter (mean follow-up 3±1.4 years). The combined endpoint was a decrease of creatinine clearance by ≥50%, end-stage renal disease with replacement therapy, or death. Twenty-five patients (15%) had a renal resistance index value ≥80 at baseline. Nineteen (76%) had a decline in renal function; 16 (64%) progressed to dialysis, and 6 (24%) died. In comparison, in patients with renal resistance index values
doi_str_mv 10.1161/hy0202.103782
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71500209</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>110372372</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5371-ef4da8414f0c8bc61f8dda91f30d0fded659ed6d93b0a7d4a6591d4cdc1202033</originalsourceid><addsrcrecordid>eNpd0M9rFTEQB_Agin1Wj15lEfS27Ux-bHaPpWpbKLQUBW8hL5n4tu7bbTNvafvfm7IPCuYwIeHDMPMV4iPCEWKDx5snkCCPEJRt5SuxQiN1rU2jXosVYKfrDvH3gXjHfAuAWmv7Vhwgtq1slF4Je0OjH6ob4p53fgxUXYyRHis_xuo6T38yMffTWE2pWuS3nskzvRdvkh-YPuzvQ_Hrx_efp-f15dXZxenJZR2MslhT0tG3GnWC0K5Dg6mN0XeYFERIkWJjulJip9bgbdS-vDHqEAOWrUCpQ_F16XuXp_uZeOe2PQcaBj_SNLOzaKDArsDP_8Hbac5lYnYSjLRKSl1QvaCQJ-ZMyd3lfuvzk0Nwz3G6JU63xFn8p33Teb2l-KL3-RXwZQ88Bz-kXCLs-cUpA50xtji9uIdp2FHmv8P8QNltyA-7jYNytGzaWj7vUgrW5cei-gfJ64rC</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>205273224</pqid></control><display><type>article</type><title>Renal Resistance Index and Progression of Renal Disease</title><source>EZB Electronic Journals Library</source><creator>Radermacher, Jörg ; Ellis, Sebastian ; Haller, Hermann</creator><creatorcontrib>Radermacher, Jörg ; Ellis, Sebastian ; Haller, Hermann</creatorcontrib><description>The progression of renal disease depends on various clinical parameters such as hypertension and proteinuria. We recently showed that an increased renal resistance index measured by duplex ultrasound is associated with a poor prognosis in patients with renal artery stenosis. We now prospectively tested the hypothesis that a high renal resistance index (≥80) predicts progression of renal disease in patients without renal artery stenosis. In 162 patients newly diagnosed with renal disease, the resistance index (1−[enddiastolic velocity/maximum systolic velocity]*100) was measured in segmental arteries of both kidneys. Creatinine clearance was measured at baseline, at 3, 6, and 12 months, and then at yearly intervals thereafter (mean follow-up 3±1.4 years). The combined endpoint was a decrease of creatinine clearance by ≥50%, end-stage renal disease with replacement therapy, or death. Twenty-five patients (15%) had a renal resistance index value ≥80 at baseline. Nineteen (76%) had a decline in renal function; 16 (64%) progressed to dialysis, and 6 (24%) died. In comparison, in patients with renal resistance index values &lt;80, 13 (9%) had a decline in renal function, only 7 (5%) became dialysis-dependent, and 2 (1%) died (P &lt;0.001). In a multivariate regression analysis, only proteinuria and resistance index were independent predictors of declining renal function. A renal resistance index value of ≥80 reliably identifies patients at risk for progressive renal disease.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/hy0202.103782</identifier><identifier>PMID: 11882634</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Aged ; Biological and medical sciences ; Disease Progression ; Humans ; Kidney Diseases - diagnostic imaging ; Kidney Diseases - pathology ; Kidney Diseases - physiopathology ; Kidney Function Tests ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Renovascular diseases ; Ultrasonography</subject><ispartof>Hypertension (Dallas, Tex. 1979), 2002-02, Vol.39 (2, Part 2 Suppl), p.699-703</ispartof><rights>2002 American Heart Association, Inc.</rights><rights>2002 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Feb 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5371-ef4da8414f0c8bc61f8dda91f30d0fded659ed6d93b0a7d4a6591d4cdc1202033</citedby><cites>FETCH-LOGICAL-c5371-ef4da8414f0c8bc61f8dda91f30d0fded659ed6d93b0a7d4a6591d4cdc1202033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=13509557$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11882634$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Radermacher, Jörg</creatorcontrib><creatorcontrib>Ellis, Sebastian</creatorcontrib><creatorcontrib>Haller, Hermann</creatorcontrib><title>Renal Resistance Index and Progression of Renal Disease</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>The progression of renal disease depends on various clinical parameters such as hypertension and proteinuria. We recently showed that an increased renal resistance index measured by duplex ultrasound is associated with a poor prognosis in patients with renal artery stenosis. We now prospectively tested the hypothesis that a high renal resistance index (≥80) predicts progression of renal disease in patients without renal artery stenosis. In 162 patients newly diagnosed with renal disease, the resistance index (1−[enddiastolic velocity/maximum systolic velocity]*100) was measured in segmental arteries of both kidneys. Creatinine clearance was measured at baseline, at 3, 6, and 12 months, and then at yearly intervals thereafter (mean follow-up 3±1.4 years). The combined endpoint was a decrease of creatinine clearance by ≥50%, end-stage renal disease with replacement therapy, or death. Twenty-five patients (15%) had a renal resistance index value ≥80 at baseline. Nineteen (76%) had a decline in renal function; 16 (64%) progressed to dialysis, and 6 (24%) died. In comparison, in patients with renal resistance index values &lt;80, 13 (9%) had a decline in renal function, only 7 (5%) became dialysis-dependent, and 2 (1%) died (P &lt;0.001). In a multivariate regression analysis, only proteinuria and resistance index were independent predictors of declining renal function. A renal resistance index value of ≥80 reliably identifies patients at risk for progressive renal disease.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Disease Progression</subject><subject>Humans</subject><subject>Kidney Diseases - diagnostic imaging</subject><subject>Kidney Diseases - pathology</subject><subject>Kidney Diseases - physiopathology</subject><subject>Kidney Function Tests</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Renovascular diseases</subject><subject>Ultrasonography</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNpd0M9rFTEQB_Agin1Wj15lEfS27Ux-bHaPpWpbKLQUBW8hL5n4tu7bbTNvafvfm7IPCuYwIeHDMPMV4iPCEWKDx5snkCCPEJRt5SuxQiN1rU2jXosVYKfrDvH3gXjHfAuAWmv7Vhwgtq1slF4Je0OjH6ob4p53fgxUXYyRHis_xuo6T38yMffTWE2pWuS3nskzvRdvkh-YPuzvQ_Hrx_efp-f15dXZxenJZR2MslhT0tG3GnWC0K5Dg6mN0XeYFERIkWJjulJip9bgbdS-vDHqEAOWrUCpQ_F16XuXp_uZeOe2PQcaBj_SNLOzaKDArsDP_8Hbac5lYnYSjLRKSl1QvaCQJ-ZMyd3lfuvzk0Nwz3G6JU63xFn8p33Teb2l-KL3-RXwZQ88Bz-kXCLs-cUpA50xtji9uIdp2FHmv8P8QNltyA-7jYNytGzaWj7vUgrW5cei-gfJ64rC</recordid><startdate>200202</startdate><enddate>200202</enddate><creator>Radermacher, Jörg</creator><creator>Ellis, Sebastian</creator><creator>Haller, Hermann</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200202</creationdate><title>Renal Resistance Index and Progression of Renal Disease</title><author>Radermacher, Jörg ; Ellis, Sebastian ; Haller, Hermann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5371-ef4da8414f0c8bc61f8dda91f30d0fded659ed6d93b0a7d4a6591d4cdc1202033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Disease Progression</topic><topic>Humans</topic><topic>Kidney Diseases - diagnostic imaging</topic><topic>Kidney Diseases - pathology</topic><topic>Kidney Diseases - physiopathology</topic><topic>Kidney Function Tests</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Renovascular diseases</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Radermacher, Jörg</creatorcontrib><creatorcontrib>Ellis, Sebastian</creatorcontrib><creatorcontrib>Haller, Hermann</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Radermacher, Jörg</au><au>Ellis, Sebastian</au><au>Haller, Hermann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal Resistance Index and Progression of Renal Disease</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>2002-02</date><risdate>2002</risdate><volume>39</volume><issue>2, Part 2 Suppl</issue><spage>699</spage><epage>703</epage><pages>699-703</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>The progression of renal disease depends on various clinical parameters such as hypertension and proteinuria. We recently showed that an increased renal resistance index measured by duplex ultrasound is associated with a poor prognosis in patients with renal artery stenosis. We now prospectively tested the hypothesis that a high renal resistance index (≥80) predicts progression of renal disease in patients without renal artery stenosis. In 162 patients newly diagnosed with renal disease, the resistance index (1−[enddiastolic velocity/maximum systolic velocity]*100) was measured in segmental arteries of both kidneys. Creatinine clearance was measured at baseline, at 3, 6, and 12 months, and then at yearly intervals thereafter (mean follow-up 3±1.4 years). The combined endpoint was a decrease of creatinine clearance by ≥50%, end-stage renal disease with replacement therapy, or death. Twenty-five patients (15%) had a renal resistance index value ≥80 at baseline. Nineteen (76%) had a decline in renal function; 16 (64%) progressed to dialysis, and 6 (24%) died. In comparison, in patients with renal resistance index values &lt;80, 13 (9%) had a decline in renal function, only 7 (5%) became dialysis-dependent, and 2 (1%) died (P &lt;0.001). In a multivariate regression analysis, only proteinuria and resistance index were independent predictors of declining renal function. A renal resistance index value of ≥80 reliably identifies patients at risk for progressive renal disease.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>11882634</pmid><doi>10.1161/hy0202.103782</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0194-911X
ispartof Hypertension (Dallas, Tex. 1979), 2002-02, Vol.39 (2, Part 2 Suppl), p.699-703
issn 0194-911X
1524-4563
language eng
recordid cdi_proquest_miscellaneous_71500209
source EZB Electronic Journals Library
subjects Aged
Biological and medical sciences
Disease Progression
Humans
Kidney Diseases - diagnostic imaging
Kidney Diseases - pathology
Kidney Diseases - physiopathology
Kidney Function Tests
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Renovascular diseases
Ultrasonography
title Renal Resistance Index and Progression of Renal Disease
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T08%3A43%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Renal%20Resistance%20Index%20and%20Progression%20of%20Renal%20Disease&rft.jtitle=Hypertension%20(Dallas,%20Tex.%201979)&rft.au=Radermacher,%20J%C3%B6rg&rft.date=2002-02&rft.volume=39&rft.issue=2,%20Part%202%20Suppl&rft.spage=699&rft.epage=703&rft.pages=699-703&rft.issn=0194-911X&rft.eissn=1524-4563&rft.coden=HPRTDN&rft_id=info:doi/10.1161/hy0202.103782&rft_dat=%3Cproquest_cross%3E110372372%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c5371-ef4da8414f0c8bc61f8dda91f30d0fded659ed6d93b0a7d4a6591d4cdc1202033%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=205273224&rft_id=info:pmid/11882634&rfr_iscdi=true