Blood Pressure Variability and Organ Damage in a General Population: Results from the PAMELA Study

In hypertensive patients, 24-hour blood pressure (BP) variability (V) shows a positive relationship with organ damage, organ damage progression, and cardiovascular morbidity. The clinical relevance of BPV in the population has never been investigated. In a sample of 3200 individuals, randomly select...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2002-02, Vol.39 (2, Part 2 Suppl), p.710-714
Main Authors: Sega, Roberto, Corrao, Giovanni, Bombelli, Michele, Beltrame, Luca, Facchetti, Rita, Grassi, Guido, Ferrario, Marco, Mancia, Giuseppe
Format: Article
Language:English
Subjects:
Adult
Aged
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Blood Pressure Monitoring, Ambulatory
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Community Health Services
Female
Humans
Male
Medical sciences
Middle Aged
Statistics as Topic
Ventricular Function, Left
Ventricular Remodeling
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Summary:In hypertensive patients, 24-hour blood pressure (BP) variability (V) shows a positive relationship with organ damage, organ damage progression, and cardiovascular morbidity. The clinical relevance of BPV in the population has never been investigated. In a sample of 3200 individuals, randomly selected from the general population of Monza (Milan, Italy), we evaluated BP by an automatic oscillometric device every 20 minutes for 24 hours and left ventricular mass index (LVMI) by echocardiography. In each subject, individual systolic and diastolic BP readings were averaged to obtain a 24-hour mean. Systolic BPV was obtained by calculating (1) the standard deviation of the 24-hour mean, which was taken as the overall BPV, (2) the cyclic components (Fourier spectral analysis) that in the population as a whole explained >95% of the overall BPV, and (3) the fraction of the overall BPV that in each subject was not accounted for by the 2 cyclic components, termed individual residual BPV. A similar procedure was used for diastolic BP and heart rate. Participation rate was 64.1%. Patients receiving antihypertensive therapy (n=403) were excluded from the analysis, which was therefore limited to 1648 participants. In the population as a whole, LVMI significantly related to 24-hour systolic and diastolic BP mean (β=0.40 and β=0.37, respectively, P
ISSN:0194-911X
1524-4563
DOI:10.1161/hy0202.104376