Guidelines for evaluation of patients at risk for inherited breast and ovarian cancer: Recommendations of the department of defense familial breast/ovarian cancer research project

Patients at high risk for inherited breast and/or ovarian cancer are frequently encountered in all medical specialties. Department of Defense, Health Affairs funding as part of the Breast Cancer Education and Awareness Program was used to develop a comprehensive program for the identification, couns...

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Bibliographic Details
Published in:Military medicine 2002-02, Vol.167 (2), p.93-98
Main Authors: FRIES, Melissa H, HOLT, Charlene, HUDSON, Gracia, CADMAN, Mary, WEATHERLY, Ronald, NUNES, Mark E, CARPENTER, Isabelle, CARTER, Cindy L, DANIELS, Jamelyn, FLANAGAN, Judith, MURPHY, Kay, HAILEY, B. Jo, MARTIN, Laura, HUME, Roderick
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Hormonal - administration & dosage
Biological and medical sciences
Breast Neoplasms - genetics
Breast Neoplasms - prevention & control
Female
Genes, BRCA1
Genes, BRCA2
Genetic Testing
Guidelines as Topic
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Mastectomy - methods
Medical sciences
Ovarian cancer
Ovarian Neoplasms - genetics
Ovarian Neoplasms - prevention & control
Pedigree
Practice Guidelines as Topic - standards
Tamoxifen - administration & dosage
Tumors
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Summary:Patients at high risk for inherited breast and/or ovarian cancer are frequently encountered in all medical specialties. Department of Defense, Health Affairs funding as part of the Breast Cancer Education and Awareness Program was used to develop a comprehensive program for the identification, counseling, genetic testing, and long-term follow-up of such high-risk patients. This article reports the recommendations for high-risk patient management based on 4 years of evaluation and care, including discussions of the approach to counseling, indications for genetic testing, post-testing counseling, patient surveillance with examination, imagining, and laboratory testing, and suggested options for surgical and chemoprophylaxis as well as lifestyle modifications.
ISSN:0026-4075
1930-613X
DOI:10.1093/milmed/167.2.93