Loading…
Association between first trimester maternal serum pregnancy associated plasma protein-A and adverse pregnancy outcome
Aims: To investigate whether low pregnancy associated plasma protein‐A (PAPP‐A) levels in the first trimester of pregnancy are associated with subsequent intrauterine fetal growth restriction, stillbirth and preterm delivery. Methods: A retrospective review of pregnancy outcomes was undertaken in...
Saved in:
| Published in: | Australian & New Zealand journal of obstetrics & gynaecology 2003-12, Vol.43 (6), p.438-442 |
|---|---|
| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c4026-6c79f06d6da291b213afbbf320b4cb4875dc2b247f6164689f6a3a297d269bb43 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c4026-6c79f06d6da291b213afbbf320b4cb4875dc2b247f6164689f6a3a297d269bb43 |
| container_end_page | 442 |
| container_issue | 6 |
| container_start_page | 438 |
| container_title | Australian & New Zealand journal of obstetrics & gynaecology |
| container_volume | 43 |
| creator | Kwik, Michele Morris, Jonathan |
| description | Aims: To investigate whether low pregnancy associated plasma protein‐A (PAPP‐A) levels in the first trimester of pregnancy are associated with subsequent intrauterine fetal growth restriction, stillbirth and preterm delivery.
Methods: A retrospective review of pregnancy outcomes was undertaken in women who had PAPP‐A carried out in the first trimester of pregnancy at the time of nuchal translucency scan. Pregnancy outcomes were assessed by the review of medical records, and postal questionnaires. Delivery details were collected, including livebirth, neonatal birthweight and gestational age at delivery. The χ2 test was used to investigate the association between low first trimester serum PAPP‐A levels and adverse fetal outcomes. Unpaired t‐test was used for continuous variables. Sensitivities and specificities were then calculated.
Results: A total of 894 women who had blood collected for PAPP‐A were identified, and data was obtained for 827 deliveries. Each had a normal karyotype. There were six intrauterine deaths, 13 babies with birthweights below the 3rd centile, 55 babies weighing below the 10th centile, and 96 women who delivered prematurely. Four of six intrauterine deaths had low PAPP‐A levels ( |
| doi_str_mv | 10.1046/j.0004-8666.2003.00126.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71504286</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71504286</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4026-6c79f06d6da291b213afbbf320b4cb4875dc2b247f6164689f6a3a297d269bb43</originalsourceid><addsrcrecordid>eNqNkUlv2zAQRomiQeOk_QsFT73JISlqKAG9uGnibEiAIktvBEmNCrlaXFJK7H8fOjaSHnPhAr435HwkhHI25UzC0WLKGJNJDgBTwVgat1zAdPWBTLhURZKL_PdHMnmF9slBCIsIFRmXn8h-hLgopJqQx1kIvavNUPcdtTg8IXa0qn0Y6ODrFsOAnrYmjp1paEA_tnTp8U9nOremZidjSZeNCa2JZ_2AdZfMqOlKaspH9AH_M_pxcH2Ln8leZZqAX3bzIbk7Pbk9Pkuububnx7OrxEkmIAGniopBCaURBbeCp6aytkoFs9JZmausdMIKqSrgICEvKjBpRFUpoLBWpofk27ZufNe_MXaj2zo4bBrTYT8GrXjGpMghgvkWdL4PwWOll7F949eaM73JXC_0Jk69iVNvMtcvmetVVL_u7hhti-WbuAs5At-3wFPd4PrdhfXs4iYuop5s9Tp-xupVN_6vBpWqTD9cz3X2Yw5wf_lL_0yfAWDgoYg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71504286</pqid></control><display><type>article</type><title>Association between first trimester maternal serum pregnancy associated plasma protein-A and adverse pregnancy outcome</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Kwik, Michele ; Morris, Jonathan</creator><creatorcontrib>Kwik, Michele ; Morris, Jonathan</creatorcontrib><description>Aims: To investigate whether low pregnancy associated plasma protein‐A (PAPP‐A) levels in the first trimester of pregnancy are associated with subsequent intrauterine fetal growth restriction, stillbirth and preterm delivery.
Methods: A retrospective review of pregnancy outcomes was undertaken in women who had PAPP‐A carried out in the first trimester of pregnancy at the time of nuchal translucency scan. Pregnancy outcomes were assessed by the review of medical records, and postal questionnaires. Delivery details were collected, including livebirth, neonatal birthweight and gestational age at delivery. The χ2 test was used to investigate the association between low first trimester serum PAPP‐A levels and adverse fetal outcomes. Unpaired t‐test was used for continuous variables. Sensitivities and specificities were then calculated.
Results: A total of 894 women who had blood collected for PAPP‐A were identified, and data was obtained for 827 deliveries. Each had a normal karyotype. There were six intrauterine deaths, 13 babies with birthweights below the 3rd centile, 55 babies weighing below the 10th centile, and 96 women who delivered prematurely. Four of six intrauterine deaths had low PAPP‐A levels (<0.5 multiples of the median), with a relative risk of 13.75. Low PAPP‐A levels were associated with fetal weight below the 10th centile (P = 0.01) but not the 3rd centile. There was no statistically significant association between low maternal serum PAPP‐A levels and preterm delivery.
Conclusion: At 11–13 weeks’ gestation, low maternal serum PAPP‐A levels are associated with fetal death in utero and birthweight below the 10th centile. First trimester PAPP‐A may be a useful tool for identifying pregnancies at risk of adverse fetal outcomes.</description><identifier>ISSN: 0004-8666</identifier><identifier>EISSN: 1479-828X</identifier><identifier>DOI: 10.1046/j.0004-8666.2003.00126.x</identifier><identifier>PMID: 14712947</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Pty</publisher><subject>Adult ; Biomarkers - blood ; Female ; Fetal Growth Retardation - blood ; Fetal Growth Retardation - diagnosis ; Gestational Age ; growth restriction ; Humans ; Obstetric Labor, Premature - blood ; Obstetric Labor, Premature - diagnosis ; Predictive Value of Tests ; Pregnancy ; pregnancy associated plasma protein-A ; Pregnancy Complications - blood ; Pregnancy Complications - diagnosis ; Pregnancy Outcome ; Pregnancy Trimester, First ; Pregnancy-Associated Plasma Protein-A - metabolism ; prematurity ; Prenatal Diagnosis - methods ; Prenatal Diagnosis - standards ; Retrospective Studies ; Sensitivity and Specificity ; stillbirth</subject><ispartof>Australian & New Zealand journal of obstetrics & gynaecology, 2003-12, Vol.43 (6), p.438-442</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4026-6c79f06d6da291b213afbbf320b4cb4875dc2b247f6164689f6a3a297d269bb43</citedby><cites>FETCH-LOGICAL-c4026-6c79f06d6da291b213afbbf320b4cb4875dc2b247f6164689f6a3a297d269bb43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14712947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwik, Michele</creatorcontrib><creatorcontrib>Morris, Jonathan</creatorcontrib><title>Association between first trimester maternal serum pregnancy associated plasma protein-A and adverse pregnancy outcome</title><title>Australian & New Zealand journal of obstetrics & gynaecology</title><addtitle>Aust N Z J Obstet Gynaecol</addtitle><description>Aims: To investigate whether low pregnancy associated plasma protein‐A (PAPP‐A) levels in the first trimester of pregnancy are associated with subsequent intrauterine fetal growth restriction, stillbirth and preterm delivery.
Methods: A retrospective review of pregnancy outcomes was undertaken in women who had PAPP‐A carried out in the first trimester of pregnancy at the time of nuchal translucency scan. Pregnancy outcomes were assessed by the review of medical records, and postal questionnaires. Delivery details were collected, including livebirth, neonatal birthweight and gestational age at delivery. The χ2 test was used to investigate the association between low first trimester serum PAPP‐A levels and adverse fetal outcomes. Unpaired t‐test was used for continuous variables. Sensitivities and specificities were then calculated.
Results: A total of 894 women who had blood collected for PAPP‐A were identified, and data was obtained for 827 deliveries. Each had a normal karyotype. There were six intrauterine deaths, 13 babies with birthweights below the 3rd centile, 55 babies weighing below the 10th centile, and 96 women who delivered prematurely. Four of six intrauterine deaths had low PAPP‐A levels (<0.5 multiples of the median), with a relative risk of 13.75. Low PAPP‐A levels were associated with fetal weight below the 10th centile (P = 0.01) but not the 3rd centile. There was no statistically significant association between low maternal serum PAPP‐A levels and preterm delivery.
Conclusion: At 11–13 weeks’ gestation, low maternal serum PAPP‐A levels are associated with fetal death in utero and birthweight below the 10th centile. First trimester PAPP‐A may be a useful tool for identifying pregnancies at risk of adverse fetal outcomes.</description><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Female</subject><subject>Fetal Growth Retardation - blood</subject><subject>Fetal Growth Retardation - diagnosis</subject><subject>Gestational Age</subject><subject>growth restriction</subject><subject>Humans</subject><subject>Obstetric Labor, Premature - blood</subject><subject>Obstetric Labor, Premature - diagnosis</subject><subject>Predictive Value of Tests</subject><subject>Pregnancy</subject><subject>pregnancy associated plasma protein-A</subject><subject>Pregnancy Complications - blood</subject><subject>Pregnancy Complications - diagnosis</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy Trimester, First</subject><subject>Pregnancy-Associated Plasma Protein-A - metabolism</subject><subject>prematurity</subject><subject>Prenatal Diagnosis - methods</subject><subject>Prenatal Diagnosis - standards</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>stillbirth</subject><issn>0004-8666</issn><issn>1479-828X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqNkUlv2zAQRomiQeOk_QsFT73JISlqKAG9uGnibEiAIktvBEmNCrlaXFJK7H8fOjaSHnPhAr435HwkhHI25UzC0WLKGJNJDgBTwVgat1zAdPWBTLhURZKL_PdHMnmF9slBCIsIFRmXn8h-hLgopJqQx1kIvavNUPcdtTg8IXa0qn0Y6ODrFsOAnrYmjp1paEA_tnTp8U9nOremZidjSZeNCa2JZ_2AdZfMqOlKaspH9AH_M_pxcH2Ln8leZZqAX3bzIbk7Pbk9Pkuububnx7OrxEkmIAGniopBCaURBbeCp6aytkoFs9JZmausdMIKqSrgICEvKjBpRFUpoLBWpofk27ZufNe_MXaj2zo4bBrTYT8GrXjGpMghgvkWdL4PwWOll7F949eaM73JXC_0Jk69iVNvMtcvmetVVL_u7hhti-WbuAs5At-3wFPd4PrdhfXs4iYuop5s9Tp-xupVN_6vBpWqTD9cz3X2Yw5wf_lL_0yfAWDgoYg</recordid><startdate>200312</startdate><enddate>200312</enddate><creator>Kwik, Michele</creator><creator>Morris, Jonathan</creator><general>Blackwell Science Pty</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200312</creationdate><title>Association between first trimester maternal serum pregnancy associated plasma protein-A and adverse pregnancy outcome</title><author>Kwik, Michele ; Morris, Jonathan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4026-6c79f06d6da291b213afbbf320b4cb4875dc2b247f6164689f6a3a297d269bb43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Female</topic><topic>Fetal Growth Retardation - blood</topic><topic>Fetal Growth Retardation - diagnosis</topic><topic>Gestational Age</topic><topic>growth restriction</topic><topic>Humans</topic><topic>Obstetric Labor, Premature - blood</topic><topic>Obstetric Labor, Premature - diagnosis</topic><topic>Predictive Value of Tests</topic><topic>Pregnancy</topic><topic>pregnancy associated plasma protein-A</topic><topic>Pregnancy Complications - blood</topic><topic>Pregnancy Complications - diagnosis</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy Trimester, First</topic><topic>Pregnancy-Associated Plasma Protein-A - metabolism</topic><topic>prematurity</topic><topic>Prenatal Diagnosis - methods</topic><topic>Prenatal Diagnosis - standards</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>stillbirth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kwik, Michele</creatorcontrib><creatorcontrib>Morris, Jonathan</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Australian & New Zealand journal of obstetrics & gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwik, Michele</au><au>Morris, Jonathan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between first trimester maternal serum pregnancy associated plasma protein-A and adverse pregnancy outcome</atitle><jtitle>Australian & New Zealand journal of obstetrics & gynaecology</jtitle><addtitle>Aust N Z J Obstet Gynaecol</addtitle><date>2003-12</date><risdate>2003</risdate><volume>43</volume><issue>6</issue><spage>438</spage><epage>442</epage><pages>438-442</pages><issn>0004-8666</issn><eissn>1479-828X</eissn><abstract>Aims: To investigate whether low pregnancy associated plasma protein‐A (PAPP‐A) levels in the first trimester of pregnancy are associated with subsequent intrauterine fetal growth restriction, stillbirth and preterm delivery.
Methods: A retrospective review of pregnancy outcomes was undertaken in women who had PAPP‐A carried out in the first trimester of pregnancy at the time of nuchal translucency scan. Pregnancy outcomes were assessed by the review of medical records, and postal questionnaires. Delivery details were collected, including livebirth, neonatal birthweight and gestational age at delivery. The χ2 test was used to investigate the association between low first trimester serum PAPP‐A levels and adverse fetal outcomes. Unpaired t‐test was used for continuous variables. Sensitivities and specificities were then calculated.
Results: A total of 894 women who had blood collected for PAPP‐A were identified, and data was obtained for 827 deliveries. Each had a normal karyotype. There were six intrauterine deaths, 13 babies with birthweights below the 3rd centile, 55 babies weighing below the 10th centile, and 96 women who delivered prematurely. Four of six intrauterine deaths had low PAPP‐A levels (<0.5 multiples of the median), with a relative risk of 13.75. Low PAPP‐A levels were associated with fetal weight below the 10th centile (P = 0.01) but not the 3rd centile. There was no statistically significant association between low maternal serum PAPP‐A levels and preterm delivery.
Conclusion: At 11–13 weeks’ gestation, low maternal serum PAPP‐A levels are associated with fetal death in utero and birthweight below the 10th centile. First trimester PAPP‐A may be a useful tool for identifying pregnancies at risk of adverse fetal outcomes.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Pty</pub><pmid>14712947</pmid><doi>10.1046/j.0004-8666.2003.00126.x</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0004-8666 |
| ispartof | Australian & New Zealand journal of obstetrics & gynaecology, 2003-12, Vol.43 (6), p.438-442 |
| issn | 0004-8666 1479-828X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71504286 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult Biomarkers - blood Female Fetal Growth Retardation - blood Fetal Growth Retardation - diagnosis Gestational Age growth restriction Humans Obstetric Labor, Premature - blood Obstetric Labor, Premature - diagnosis Predictive Value of Tests Pregnancy pregnancy associated plasma protein-A Pregnancy Complications - blood Pregnancy Complications - diagnosis Pregnancy Outcome Pregnancy Trimester, First Pregnancy-Associated Plasma Protein-A - metabolism prematurity Prenatal Diagnosis - methods Prenatal Diagnosis - standards Retrospective Studies Sensitivity and Specificity stillbirth |
| title | Association between first trimester maternal serum pregnancy associated plasma protein-A and adverse pregnancy outcome |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T02%3A54%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20first%20trimester%20maternal%20serum%20pregnancy%20associated%20plasma%20protein-A%20and%20adverse%20pregnancy%20outcome&rft.jtitle=Australian%20&%20New%20Zealand%20journal%20of%20obstetrics%20&%20gynaecology&rft.au=Kwik,%20Michele&rft.date=2003-12&rft.volume=43&rft.issue=6&rft.spage=438&rft.epage=442&rft.pages=438-442&rft.issn=0004-8666&rft.eissn=1479-828X&rft_id=info:doi/10.1046/j.0004-8666.2003.00126.x&rft_dat=%3Cproquest_cross%3E71504286%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4026-6c79f06d6da291b213afbbf320b4cb4875dc2b247f6164689f6a3a297d269bb43%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=71504286&rft_id=info:pmid/14712947&rfr_iscdi=true |