A Microbial Strategy to Multiply in Macrophages: The Pregnant Pause

Humans live in harmony with much of the microbial world, thanks to a sophisticated immune system. As the first line of defense, macrophages engulf, digest, and display foreign material, then recruit specialists to eliminate potential threats. Yet infiltrators exist: certain fungi, viruses, parasites...

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Bibliographic Details
Published in:Traffic (Copenhagen, Denmark) Denmark), 2002-03, Vol.3 (3), p.170-177
Main Authors: Swanson, Michele S., Fernandez‐Moreia, Esteban
Format: Article
Language:English
Subjects:
Actins - metabolism
Animals
autophagy
Coxiella
Coxiella burnetii - metabolism
Humans
Legionella
Legionella pneumophila - metabolism
Leishmania
Leishmania - metabolism
lysosomes
Lysosomes - microbiology
macrophages
Macrophages - microbiology
Macrophages - physiology
Models, Biological
morphogenesis
Phagocytosis
phagosomes
Phagosomes - microbiology
Phenotype
Time Factors
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Summary:Humans live in harmony with much of the microbial world, thanks to a sophisticated immune system. As the first line of defense, macrophages engulf, digest, and display foreign material, then recruit specialists to eliminate potential threats. Yet infiltrators exist: certain fungi, viruses, parasites, and bacteria thrive within sentinel macrophages. By scrutinizing the life styles of these shrewd microbes, we can deduce how macrophages routinely mount an effective immune response. The bimorphic life cycles of three pathogens have dramatic consequences for phagosome traffic. In the transmissible state, Leishmania spp., Coxiella burnetii, and Legionella pneumophila block phagosome maturation; after a pregnant pause, replicative forms emerge and thrive in lysosomes.
ISSN:1398-9219
1600-0854
DOI:10.1034/j.1600-0854.2002.030302.x