Structure and pharmacology of swelling-sensitive chloride channels, I(Cl,swell)

Since several years, the interest for chloride channels and more particularly for the enigmatic swelling-activated chloride channel (I(Cl,swell)) is increasing. Despite its well-characterized electrophysiological properties, the I(Cl,swell) structure and pharmacology are not totally elucidated. Thes...

Full description

Saved in:
Bibliographic Details
Published in:Fundamental & clinical pharmacology 2003-10, Vol.17 (5), p.539-553
Main Authors: d'Anglemont de Tassigny, Alexandra, Souktani, Rachid, Ghaleh, Bijan, Henry, Patrick, Berdeaux, Alain
Format: Article
Language:English
Subjects:
Animals
Cell Size - drug effects
Cell Size - physiology
Chloride Channels - antagonists & inhibitors
Chloride Channels - chemistry
Chloride Channels - metabolism
Humans
Ion Channel Gating - drug effects
Ion Channel Gating - physiology
Signal Transduction - drug effects
Signal Transduction - physiology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Since several years, the interest for chloride channels and more particularly for the enigmatic swelling-activated chloride channel (I(Cl,swell)) is increasing. Despite its well-characterized electrophysiological properties, the I(Cl,swell) structure and pharmacology are not totally elucidated. These channels are involved in a variety of cell functions, such as cardiac rhythm, cell proliferation and differentiation, cell volume regulation and cell death through apoptosis. This review will consider different aspects regarding structure, electrophysiological properties, pharmacology, modulation and functions of these swelling-activated chloride channels.
ISSN:0767-3981