Recurrent Sphingomonas paucimobilis -bacteraemia associated with a multi-bacterial water-borne epidemic among neutropenic patients

A cluster of septicaemias due to several water-related species occurred in a haematological unit of a university hospital. In recurrent septicaemias of a leukaemic patient caused by Sphingomonas paucimobilis, genotyping of the blood isolates by use of random amplified polymorphic DNA-analysis verifi...

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Bibliographic Details
Published in:The Journal of hospital infection 2002-03, Vol.50 (3), p.196-201
Main Authors: Perola, O., Nousiainen, T., Suomalainen, S., Aukee, S., Kärkkäinen, U.-M., Kauppinen, J., Ojanen, T., Katila, M.-L.
Format: Article
Language:English
Subjects:
Bacteremia - epidemiology
Bacteremia - etiology
Bacterial diseases
Bacterial sepsis
Biological and medical sciences
Cross Infection - epidemiology
Cross Infection - etiology
Female
Gram-Negative Bacterial Infections - epidemiology
Gram-Negative Bacterial Infections - etiology
Hematologic and hematopoietic diseases
Human bacterial diseases
Humans
Infectious diseases
Leukemia - immunology
Medical sciences
Middle Aged
Neutropenia
Opportunistic Infections - epidemiology
Opportunistic Infections - etiology
Other diseases. Hematologic involvement in other diseases
Random Amplified Polymorphic DNA Technique
Recurrence
RNA, Ribosomal, 16S
Sphingomonas - genetics
Sphingomonas - isolation & purification
Sphingomonas, bacteraemia, nosocomial infection, random amplified polymorphic DNA technique
Water Microbiology
Water Supply
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Summary:A cluster of septicaemias due to several water-related species occurred in a haematological unit of a university hospital. In recurrent septicaemias of a leukaemic patient caused by Sphingomonas paucimobilis, genotyping of the blood isolates by use of random amplified polymorphic DNA-analysis verified the presence of two distinct S. paucimobilis strains during two of the separate episodes. A strain of S. paucimobilis identical to one of the patient's was isolated from tap water collected in the haematological unit. Thus S. paucimobilis present in blood cultures was directly linked to bacterial colonization of the hospital water system. Heterogeneous finger-printing patterns among the clinical and environmental isolates indicated the distribution of a variety of S. paucimobilis clones in the hospital environment. This link also explained the multi-microbial nature of the outbreak.
ISSN:0195-6701
1532-2939
DOI:10.1053/jhin.2001.1163