Prognostic factors in soft tissue sarcomas: a study of 395 patients

Aims: The aim of this study was to report prognostic factors, end-points of local recurrence, distant recurrence, post-metastasis survival, and overall survival in a cohort of patients with soft tissue sarcomas. Methods:We analysed a database of 395 patients affected by primary soft tissue sarcomas...

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Bibliographic Details
Published in:European journal of surgical oncology 2002-03, Vol.28 (2), p.153-164
Main Authors: Stefanovski, P.D., Bidoli, E., De Paoli, A., Buonadonna, A., Boz, G., Libra, M., Morassut, S., Rossi, C., Carbone, A., Frustaci, S.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Analysis of Variance
Biological and medical sciences
Child
Combined Modality Therapy
Female
Humans
Incidence
Italy - epidemiology
Male
Medical sciences
Middle Aged
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Multivariate Analysis
Neoplasm Staging
Probability
Prognosis
prognostic factors
Proportional Hazards Models
Registries
Retrospective Studies
Risk Factors
Sarcoma - diagnosis
Sarcoma - epidemiology
Sarcoma - therapy
Sex Distribution
soft tissue sarcomas
Survival Analysis
Tumors
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Summary:Aims: The aim of this study was to report prognostic factors, end-points of local recurrence, distant recurrence, post-metastasis survival, and overall survival in a cohort of patients with soft tissue sarcomas. Methods:We analysed a database of 395 patients affected by primary soft tissue sarcomas of various primary sites, treated and followed up at the Centro di Riferimento Oncologico, Aviano, Italy from January 1985 to January 1997. Results: Grade, size, stage, surgical margins, distant metastasis, age, sex, performance status, and haemoglobin value were significant for overall survival. Histology, grade, stage, and surgical margins were significant for local recurrence. Grade, size, and stage, were significant for distant recurrence; and surgical margin was significant variable for post-metastasis survival. Conclusions: Grade, size, and TNM stage (UICC/AJCC) have stronger prognostic significance for overall survival and distant recurrence than for local relapse. Positive surgical margins are the main predictors for local relapse. Age was the most consistent adverse independent prognostic factor for survival.
ISSN:0748-7983
1532-2157
DOI:10.1053/ejso.2001.1242