Cytokine pattern in postmenopause

Objective: The present study was undertaken to evaluate the pattern of serum cytokine production in postmenopausal women and the relationship with the hormonal status. A group of fertile women served as controls. Methods: Eighty-two women in apparent good health, non-smokers and without a history of...

Full description

Saved in:
Bibliographic Details
Published in:Maturitas 2002-03, Vol.41 (3), p.187-192
Main Authors: Cioffi, Michele, Esposito, Katherine, Vietri, Maria Teresa, Gazzerro, Patrizia, D'Auria, Annamaria, Ardovino, Italo, Puca, Giovanni Alfredo, Molinari, Anna Maria
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Case-Control Studies
Cytokines - blood
Dehydroepiandrosterone - blood
Dehydroepiandrosterone Sulfate - blood
Enzyme-Linked Immunosorbent Assay
Estradiol - blood
Female
Fertility
Follicle Stimulating Hormone - blood
Fundamental and applied biological sciences. Psychology
Growth Hormone - blood
Humans
Insulin-Like Growth Factor I - metabolism
Interleukin-18 - blood
Interleukin-6 - blood
Luteinizing Hormone - blood
Middle Aged
Postmenopausal
Postmenopause - blood
Progesterone - blood
Serum cytokine
Sex hormones
Sexual differentiation and maturation. Puberty. Climacterium
Surveys and Questionnaires
Tumor Necrosis Factor-alpha - metabolism
Vertebrates: reproduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: The present study was undertaken to evaluate the pattern of serum cytokine production in postmenopausal women and the relationship with the hormonal status. A group of fertile women served as controls. Methods: Eighty-two women in apparent good health, non-smokers and without a history of hormone replacement therapy, were enrolled for the study. The women were divided in two groups according to their hormonal status: fertile women ( n=34, age 32±7 years) and postmenopausal women ( n=48, age 54±8 years). Blood samples were withdrawn in the morning, after an overnight fast. Results: Sex hormones (LH, FSH, Estradiol, Progesterone, DHEA, DHEA-S), as well as GH and IGF-1 levels, were significantly higher in the serum of fertile women as compared with their postmenopausal counterparts. Unlike IL-2, IL-4, IL-5, IL-10, IL-12 and IFN-γ, significant differences were observed in serum IL-6, IL-18, TNFα and TNFβ between groups: both IL-6 and IL-18 were higher in postmenopausal women, while TNFα and TNFβ were significantly lower. There was an inverse relationship between serum DHEA and DHEA-S levels and both IL-6 ( r=−0.46, P
ISSN:0378-5122
1873-4111
DOI:10.1016/S0378-5122(01)00286-9