Biochemical markers of types I and III collagen and limited joint mobility in type 1 diabetic patients

Limited joint mobility (LJM), a long-term complication of diabetes, has been shown to be associated with microvascular complications of diabetes. Connective tissue alterations may contribute to the development of LJM and other diabetic complications. We tested whether biochemical markers of types I...

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Bibliographic Details
Published in:Acta diabetologica 2003-12, Vol.40 (4), p.151-155
Main Authors: ARKKILA, P. E. T, KOSKINEN, P. J, KANTOLA, I. M, RÖNNEMAA, T, SEPPÄNEN, E, VIIKARI, J. S. A
Format: Article
Language:English
Subjects:
Adult
Age of Onset
Aged
Amino Acids - urine
Biochemistry
Biological and medical sciences
Biomarkers - blood
Biomarkers - urine
Collagen - urine
Collagen Type I
Comparative studies
Creatinine - blood
Creatinine - urine
Diabetes
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - urine
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Genetic markers
Humans
Joint Diseases - blood
Joint Diseases - etiology
Joint Diseases - urine
Joints
Male
Medical sciences
Men
Metabolism
Middle Aged
Mobility
Patients
Peptide Fragments - blood
Peptides - urine
Procollagen - blood
Proteins
Citations: Items that cite this one
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Summary:Limited joint mobility (LJM), a long-term complication of diabetes, has been shown to be associated with microvascular complications of diabetes. Connective tissue alterations may contribute to the development of LJM and other diabetic complications. We tested whether biochemical markers of types I and III collagen metabolism are associated with LJM in type 1 diabetes. We studied 28 male patients of mean age 43.4 years (SD=9.5) and with a duration of diabetes of 25.2 years (SD=9.7) years. LJM assessment included goniometric measurements of the joints and classification by Rosenbloom's method. We measured serum concentrations of aminoterminal propeptide of type III procollagen (PIIINP), carboxyterminal propeptide of type I procollagen (PICP) and carboxyterminal crosslinked telopeptide of type I collagen (ICTP); urinary excretion of crosslinked N-telopeptides of type I collagen (NTX) and deoxypyridinoline crosslinks (DPyr) was also measured. Although average serum PIIINP tended to be higher in subjects with moderate-severe LJM (3.1 +/- 1.3 microg/l) than in subjects with mild LJM (2.5 +/- 0.7 microg/l) or without LJM (2.6 +/- 0.4 microg/l), no significant association was found (p
ISSN:0940-5429
1432-5233
DOI:10.1007/s00592-003-0104-0