Chronic granulomatous lung infection caused by the dimorphic fungus Emmonsia sp

A 64-year old farmer developed cough, dyspnoea on exertion, and recurrent febrile episodes. X-ray and CT scan revealed bilateral lower lobe opacities in his lungs. A transbronchial biopsy was performed and histopathological findings were interpreted as consistent with a pulmonary necrotizing clear-c...

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Bibliographic Details
Published in:International journal of medical microbiology 2003-12, Vol.293 (6), p.441-445
Main Authors: Wellinghausen, Nele, Kern, Winfried V., Haase, Gerhard, Rozdzinski, Eva, Kern, Peter, Marre, Reinhard, Essig, Andreas, Hetzel, Jürgen, Hetzel, Martin
Format: Article
Language:English
Subjects:
adiaspiromycosis
Antifungal Agents - therapeutic use
Biological and medical sciences
Chronic granulomatous disease
Chrysosporium - classification
Chrysosporium - genetics
Chrysosporium - isolation & purification
DNA, Ribosomal - analysis
dyspnoea
Emmonsia
Fundamental and applied biological sciences. Psychology
granuloma
Granulomatous Disease, Chronic - drug therapy
Granulomatous Disease, Chronic - microbiology
Humans
itraconazole
Itraconazole - therapeutic use
lung biopsy
Lung Diseases, Fungal - drug therapy
Lung Diseases, Fungal - microbiology
Male
Microbiology
Middle Aged
Miscellaneous
Molecular Sequence Data
Mycology
Mycoses - drug therapy
Mycoses - microbiology
Pneumocystis carinii
RNA, Ribosomal, 18S - genetics
Sequence Analysis, DNA
transbronchial biopsy
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Summary:A 64-year old farmer developed cough, dyspnoea on exertion, and recurrent febrile episodes. X-ray and CT scan revealed bilateral lower lobe opacities in his lungs. A transbronchial biopsy was performed and histopathological findings were interpreted as consistent with a pulmonary necrotizing clear-cell carcinoma and later as a Pneumocystis carinii pneumonia. Due to persistence of symptoms, six months later another lung biopsy was performed and a mould was cultured which was identified by 18S rDNA sequencing as Emmonsia sp. The patient showed some improvement under itraconazole treatment. This is the first description of a human infection with Emmonsia sp. in Germany.
ISSN:1438-4221
1618-0607
DOI:10.1078/1438-4221-00281