Axon guidance: the cytoplasmic tail

Recent advances in the study of axon guidance have begun to clarify the intricate signalling mechanisms utilised by receptors that mediate path-finding. Many of these axon guidance receptors, including Plexin B, EphA, ephrin B and Robo, regulate the Rho family of GTPases, to effect changes in motili...

Full description

Saved in:
Bibliographic Details
Published in:Current Opinion in Cell Biology 2002-04, Vol.14 (2), p.221-229
Main Authors: Patel, Bharatkumar N, Van Vactor, David L
Format: Article
Language:English
Subjects:
Animals
Axon guidance
Axons - physiology
ephrin B
growth cone motility
GTP Phosphohydrolases - metabolism
Humans
Plexin B
Receptor Cross-Talk - physiology
receptor signalling
Rho GTPases
Robo
Signal Transduction - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Recent advances in the study of axon guidance have begun to clarify the intricate signalling mechanisms utilised by receptors that mediate path-finding. Many of these axon guidance receptors, including Plexin B, EphA, ephrin B and Robo, regulate the Rho family of GTPases, to effect changes in motility. Recent studies demonstrate a critical role for the cytoplasmic tails of guidance receptors in signalling and also reveal the potential for a great deal of crosstalk between the various receptor-signalling pathways. Recent advances have begun to clarify the signalling mechanisms utilised by axon guidance, and to reveal a critical role for the cytoplasmic tail of these receptors in the signalling process.
ISSN:0955-0674
1879-0410
DOI:10.1016/S0955-0674(02)00308-3