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Axon guidance: the cytoplasmic tail

Recent advances in the study of axon guidance have begun to clarify the intricate signalling mechanisms utilised by receptors that mediate path-finding. Many of these axon guidance receptors, including Plexin B, EphA, ephrin B and Robo, regulate the Rho family of GTPases, to effect changes in motili...

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Published in:	Current Opinion in Cell Biology 2002-04, Vol.14 (2), p.221-229
Main Authors:	Patel, Bharatkumar N, Van Vactor, David L
Format:	Article
Language:	English
Subjects:	Animals Axon guidance Axons - physiology ephrin B growth cone motility GTP Phosphohydrolases - metabolism Humans Plexin B Receptor Cross-Talk - physiology receptor signalling Rho GTPases Robo Signal Transduction - physiology
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description	Recent advances in the study of axon guidance have begun to clarify the intricate signalling mechanisms utilised by receptors that mediate path-finding. Many of these axon guidance receptors, including Plexin B, EphA, ephrin B and Robo, regulate the Rho family of GTPases, to effect changes in motility. Recent studies demonstrate a critical role for the cytoplasmic tails of guidance receptors in signalling and also reveal the potential for a great deal of crosstalk between the various receptor-signalling pathways. Recent advances have begun to clarify the signalling mechanisms utilised by axon guidance, and to reveal a critical role for the cytoplasmic tail of these receptors in the signalling process.
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subjects	Animals Axon guidance Axons - physiology ephrin B growth cone motility GTP Phosphohydrolases - metabolism Humans Plexin B Receptor Cross-Talk - physiology receptor signalling Rho GTPases Robo Signal Transduction - physiology
title	Axon guidance: the cytoplasmic tail
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