COMPARE: a web accessible tool for investigating mechanisms of cell growth inhibition

For more than 10 years the National Cancer Institute (NCI) has tested compounds for their ability to inhibit the growth of human tumor cell lines in culture (NCI screen). Work of Ken Paull [J. Natl. Cancer Inst. 81 (1989) 1088] demonstrated that compounds with similar mechanism of cell growth inhibi...

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Bibliographic Details
Published in:Journal of molecular graphics & modelling 2002, Vol.20 (4), p.297-303
Main Authors: Zaharevitz, Daniel W., Holbeck, Susan L., Bowerman, Christopher, Svetlik, Penny A.
Format: Article
Language:English
Subjects:
Algorithms
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antitumor drugs
Cell-based screening
COMPARE
Correlation analysis
Data Interpretation, Statistical
Databases, Factual
Drug discovery
Drug Evaluation, Preclinical
Growth Inhibitors - chemistry
Growth Inhibitors - pharmacology
Humans
Internet
Linear Models
Software
Tumor Cells, Cultured
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Summary:For more than 10 years the National Cancer Institute (NCI) has tested compounds for their ability to inhibit the growth of human tumor cell lines in culture (NCI screen). Work of Ken Paull [J. Natl. Cancer Inst. 81 (1989) 1088] demonstrated that compounds with similar mechanism of cell growth inhibition show similar patterns of activity in the NCI screen. This observation was developed into an algorithm called COMPARE and has been successfully used to predict mechanisms for a wide variety of compounds. More recently, this method has been extended to associate patterns of cell growth inhibition by compounds with measurements of molecular entities (such as gene expression) in the cell lines in the NCI screen. The COMPARE method and associated data are freely available on the Developmental Therapeutics Program (DTP) web site ( http://dtp.nci.nih.gov/). Examples of the use of COMPARE on these web pages will be explained and demonstrated.
ISSN:1093-3263
1873-4243
DOI:10.1016/S1093-3263(01)00126-7