Clinical Outcomes of Critical Illness Polyneuropathy

It is often difficult to isolate the origin of acute weakness in the critically ill population because of multiple etiologies. Aminoglycosides, corticosteroids, and neuromuscular blockers frequently are implicated as the source of acute weakness. Recently, critical illness polyneuropathy (CIP), a sy...

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Bibliographic Details
Published in:Pharmacotherapy 2002-03, Vol.22 (3), p.373-379
Main Authors: Kane, Sandra L., Dasta, Joseph F.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Clinical Trials as Topic
Electromyography
Humans
Intensive Care Units
Length of Stay
Male
Medical sciences
Multiple Organ Failure - complications
Muscle Weakness - complications
Muscle Weakness - therapy
Nervous system involvement in other diseases. Miscellaneous
Neurology
Phrenic Nerve - physiology
Polyneuropathies - complications
Polyneuropathies - physiopathology
Polyneuropathies - therapy
Respiration, Artificial
Retrospective Studies
Sepsis - complications
Sepsis - physiopathology
Systemic Inflammatory Response Syndrome - diagnosis
Systemic Inflammatory Response Syndrome - physiopathology
Ventilator Weaning
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Summary:It is often difficult to isolate the origin of acute weakness in the critically ill population because of multiple etiologies. Aminoglycosides, corticosteroids, and neuromuscular blockers frequently are implicated as the source of acute weakness. Recently, critical illness polyneuropathy (CIP), a syndrome of unknown etiology, was added to the differential diagnosis. The frequency of CIP is approximately 70% in patients with sepsis. Early studies of CIP, which were mostly retrospective, underestimated its frequency due to the complexity of the diagnosis and unfamiliarity with the syndrome. Prospective studies have explored the causality and clinical outcomes of CIP. Clinical outcomes of patients with CIP include difficulty weaning from mechanical ventilation, increased length of stay, prolonged recovery, and an overall mortality rate of 26–71%. The association of CIP with sepsis, multiorgan failure, and drugs is still unclear.
ISSN:0277-0008
1875-9114
DOI:10.1592/phco.22.5.373.33199