Vitamin D receptor gene polymorphisms in breast cancer

Breast cancer is the leading cause of cancer death among women around the world and its incidence is annually increasing. The vitamin D receptor (VDR) gene is a member of the nuclear receptor superfamily, which is expressed in breast tissue and known to modulate the rate of cell proliferation. Assoc...

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Bibliographic Details
Published in:Experimental & molecular medicine 2003-12, Vol.35 (6), p.550-555
Main Authors: Buyru, Nur, Tezol, Ayda, Yosunkaya-Fenerci, Elif, Dalay, Nejat
Format: Article
Language:English
Subjects:
Breast cancer
Breast Neoplasms - genetics
Gene Frequency
Genotype
Humans
Polymerase Chain Reaction
Polymorphism, Genetic - genetics
Receptors, Calcitriol - genetics
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Summary:Breast cancer is the leading cause of cancer death among women around the world and its incidence is annually increasing. The vitamin D receptor (VDR) gene is a member of the nuclear receptor superfamily, which is expressed in breast tissue and known to modulate the rate of cell proliferation. Association between the VDR gene polymorphisms and cancer development has been suggested by several studies. However, the relationship between VDR polymorphisms and breast cancer is controversial and has not been confirmed by all studies. The purpose of this study was to investigate the genotype frequencies and association of the VDR Bsm I and Taq I polymorphisms with breast cancer in Turkish patients. In this study, 78 patients with breast cancer and 27 healthy individuals were enrolled. The prevalence of the VDR Taq I and Bsm I alleles and the genotype frequencies in patients with breast cancer was similar to that in the normal population. Our data indicate that no significant differences exist between the patients and control subjects.
ISSN:1226-3613
2092-6413
2092-6413
DOI:10.1038/emm.2003.72