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An endogenous retrovirus derived from human melanoma cells
We show that human melanoma cells produce retrovirus-like particles that exhibit reverse transcriptase activity, package sequences homologous to human endogenous retrovirus K (HERV-K), and contain mature forms of the Gag and Env proteins. We also demonstrate expression of the pol gene and of Gag, En...
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| Published in: | Cancer research (Chicago, Ill.) Ill.), 2003-12, Vol.63 (24), p.8735-8741 |
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| Main Authors: | , , , , , , , , , , , , , |
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| Language: | English |
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| container_end_page | 8741 |
| container_issue | 24 |
| container_start_page | 8735 |
| container_title | Cancer research (Chicago, Ill.) |
| container_volume | 63 |
| creator | MUSTER, Thomas WALTENBERGER, Andrea LÖWER, Roswitha JANSEN, Burkhard PEHAMBERGER, Hubert WOLFF, Klaus GRASSAUER, Andreas HIRSCHL, Sonja CAUCIG, Peri ROMIRER, Ingrid FÖDINGER, Dagmar SEPPELE, Heide SCHANAB, Oliver MAGIN-LACHMANN, Christine |
| description | We show that human melanoma cells produce retrovirus-like particles that exhibit reverse transcriptase activity, package sequences homologous to human endogenous retrovirus K (HERV-K), and contain mature forms of the Gag and Env proteins. We also demonstrate expression of the pol gene and of Gag, Env, and Rec proteins in human melanomas and metastases but not in melanocytes or normal lymph nodes. The data suggest that expression of retroviral genes and production of retroviral particles is activated during development of melanoma. |
| format | article |
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We also demonstrate expression of the pol gene and of Gag, Env, and Rec proteins in human melanomas and metastases but not in melanocytes or normal lymph nodes. The data suggest that expression of retroviral genes and production of retroviral particles is activated during development of melanoma.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>PMID: 14695188</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Antineoplastic agents ; Base Sequence ; Biological and medical sciences ; Endogenous Retroviruses - genetics ; Endogenous Retroviruses - isolation & purification ; Endogenous Retroviruses - metabolism ; Gene Products, env - biosynthesis ; Gene Products, gag - biosynthesis ; Gene Products, pol - biosynthesis ; Human endogenous retrovirus ; Humans ; Lymphatic Metastasis ; Medical sciences ; Melanoma - metabolism ; Melanoma - secondary ; Melanoma - virology ; Molecular Sequence Data ; Pharmacology. Drug treatments ; Sequence Homology, Nucleic Acid ; Skin Neoplasms - metabolism ; Skin Neoplasms - secondary ; Skin Neoplasms - virology ; Tumors</subject><ispartof>Cancer research (Chicago, Ill.), 2003-12, Vol.63 (24), p.8735-8741</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15382622$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14695188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MUSTER, Thomas</creatorcontrib><creatorcontrib>WALTENBERGER, Andrea</creatorcontrib><creatorcontrib>LÖWER, Roswitha</creatorcontrib><creatorcontrib>JANSEN, Burkhard</creatorcontrib><creatorcontrib>PEHAMBERGER, Hubert</creatorcontrib><creatorcontrib>WOLFF, Klaus</creatorcontrib><creatorcontrib>GRASSAUER, Andreas</creatorcontrib><creatorcontrib>HIRSCHL, Sonja</creatorcontrib><creatorcontrib>CAUCIG, Peri</creatorcontrib><creatorcontrib>ROMIRER, Ingrid</creatorcontrib><creatorcontrib>FÖDINGER, Dagmar</creatorcontrib><creatorcontrib>SEPPELE, Heide</creatorcontrib><creatorcontrib>SCHANAB, Oliver</creatorcontrib><creatorcontrib>MAGIN-LACHMANN, Christine</creatorcontrib><title>An endogenous retrovirus derived from human melanoma cells</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>We show that human melanoma cells produce retrovirus-like particles that exhibit reverse transcriptase activity, package sequences homologous to human endogenous retrovirus K (HERV-K), and contain mature forms of the Gag and Env proteins. We also demonstrate expression of the pol gene and of Gag, Env, and Rec proteins in human melanomas and metastases but not in melanocytes or normal lymph nodes. The data suggest that expression of retroviral genes and production of retroviral particles is activated during development of melanoma.</description><subject>Antineoplastic agents</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Endogenous Retroviruses - genetics</subject><subject>Endogenous Retroviruses - isolation & purification</subject><subject>Endogenous Retroviruses - metabolism</subject><subject>Gene Products, env - biosynthesis</subject><subject>Gene Products, gag - biosynthesis</subject><subject>Gene Products, pol - biosynthesis</subject><subject>Human endogenous retrovirus</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Medical sciences</subject><subject>Melanoma - metabolism</subject><subject>Melanoma - secondary</subject><subject>Melanoma - virology</subject><subject>Molecular Sequence Data</subject><subject>Pharmacology. Drug treatments</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Skin Neoplasms - metabolism</subject><subject>Skin Neoplasms - secondary</subject><subject>Skin Neoplasms - virology</subject><subject>Tumors</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqF0E1LxDAQBuAgiruu_gXpRW-FfCf1tiy6Cgte9l7SZOpWmnRN2gX_vRErHj3NDDwMM-8ZWhLBdKk4F-doiTHWpeCKLtBVSu95FASLS7QgXFaCaL1ED-tQQHDDG4RhSkWEMQ6nLubWQexO4Io2Dr44TN6EwkNvwuBNYaHv0zW6aE2f4GauK7R_etxvnsvd6_Zls96VB4bpWEorOWWCOOMsk60GpRzFQholdaMrLhtbaWUNgUpzJYAJLplljQEhlVRshe5_1h7j8DFBGmvfpe8DTIB8cq3yxxhz_C8kSgnKJc3wdoZT48HVx9h5Ez_r31QyuJuBSdb0bTTBdunP5YippJR9Ae7xaqc</recordid><startdate>20031215</startdate><enddate>20031215</enddate><creator>MUSTER, Thomas</creator><creator>WALTENBERGER, Andrea</creator><creator>LÖWER, Roswitha</creator><creator>JANSEN, Burkhard</creator><creator>PEHAMBERGER, Hubert</creator><creator>WOLFF, Klaus</creator><creator>GRASSAUER, Andreas</creator><creator>HIRSCHL, Sonja</creator><creator>CAUCIG, Peri</creator><creator>ROMIRER, Ingrid</creator><creator>FÖDINGER, Dagmar</creator><creator>SEPPELE, Heide</creator><creator>SCHANAB, Oliver</creator><creator>MAGIN-LACHMANN, Christine</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20031215</creationdate><title>An endogenous retrovirus derived from human melanoma cells</title><author>MUSTER, Thomas ; WALTENBERGER, Andrea ; LÖWER, Roswitha ; JANSEN, Burkhard ; PEHAMBERGER, Hubert ; WOLFF, Klaus ; GRASSAUER, Andreas ; HIRSCHL, Sonja ; CAUCIG, Peri ; ROMIRER, Ingrid ; FÖDINGER, Dagmar ; SEPPELE, Heide ; SCHANAB, Oliver ; MAGIN-LACHMANN, Christine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h302t-6c642351dadc36f8e77d2056a768b8946bc987ca1e98475e35463c3bae567673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Antineoplastic agents</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Endogenous Retroviruses - genetics</topic><topic>Endogenous Retroviruses - isolation & purification</topic><topic>Endogenous Retroviruses - metabolism</topic><topic>Gene Products, env - biosynthesis</topic><topic>Gene Products, gag - biosynthesis</topic><topic>Gene Products, pol - biosynthesis</topic><topic>Human endogenous retrovirus</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Medical sciences</topic><topic>Melanoma - metabolism</topic><topic>Melanoma - secondary</topic><topic>Melanoma - virology</topic><topic>Molecular Sequence Data</topic><topic>Pharmacology. 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We also demonstrate expression of the pol gene and of Gag, Env, and Rec proteins in human melanomas and metastases but not in melanocytes or normal lymph nodes. The data suggest that expression of retroviral genes and production of retroviral particles is activated during development of melanoma.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>14695188</pmid><tpages>7</tpages></addata></record> |
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| ispartof | Cancer research (Chicago, Ill.), 2003-12, Vol.63 (24), p.8735-8741 |
| issn | 0008-5472 1538-7445 |
| language | eng |
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| source | EZB Electronic Journals Library |
| subjects | Antineoplastic agents Base Sequence Biological and medical sciences Endogenous Retroviruses - genetics Endogenous Retroviruses - isolation & purification Endogenous Retroviruses - metabolism Gene Products, env - biosynthesis Gene Products, gag - biosynthesis Gene Products, pol - biosynthesis Human endogenous retrovirus Humans Lymphatic Metastasis Medical sciences Melanoma - metabolism Melanoma - secondary Melanoma - virology Molecular Sequence Data Pharmacology. Drug treatments Sequence Homology, Nucleic Acid Skin Neoplasms - metabolism Skin Neoplasms - secondary Skin Neoplasms - virology Tumors |
| title | An endogenous retrovirus derived from human melanoma cells |
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