Comparison of LDL fatty acid and carotenoid concentrations and oxidative resistance of LDL in volunteers from countries with different rates of cardiovascular disease

Within Europe there are differences in cardiovascular disease (CVD) risk between countries and this might be related to dietary habits. Oxidative modification of LDL is suggested to increase the risk of CVD and both the fatty acid and antioxidant content of LDL can affect its oxidation. In the prese...

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Bibliographic Details
Published in:British journal of nutrition 2002-01, Vol.87 (1), p.21-29
Main Authors: Wright, Anthony J. A., Southon, Susan, Chopra, Mridula, Meyer-Wenger, Anita, Moser, Ulrich, Granado, Fernando, Olmedilla, Begoña, Corridan, Bernice, Hinninger, Isabelle, Roussel, Anne-Marie, van den Berg, Henk, Thurnham, David I.
Format: Article
Language:English
Subjects:
Adult
Antioxidants
Antioxidants - metabolism
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cardiopathies: etiologic forms (general aspects and miscellaneous)
Cardiovascular diseases
Cardiovascular Diseases - blood
Carotenoids
Carotenoids - blood
Copper - pharmacology
Europe
Fatty acids
Female
Heart
Humans
LDL oxidation
Lipid Peroxidation - drug effects
Lipoproteins, LDL - blood
Male
Medical sciences
Micronutrients
Middle Aged
Miscellaneous
Oxidation
Oxidation-Reduction
Risk Factors
Tocopherols
Tocopherols - blood
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Summary:Within Europe there are differences in cardiovascular disease (CVD) risk between countries and this might be related to dietary habits. Oxidative modification of LDL is suggested to increase the risk of CVD and both the fatty acid and antioxidant content of LDL can affect its oxidation. In the present study, concentration of LDL fatty acid and antioxidant micronutrients (tocopherols and carotenoids) and ex vivo oxidative resistance of LDL (lag phase) was compared in volunteers from five countries with different fruit and vegetable intakes and reported rates of CVD. Eighty volunteers (forty males, forty females per centre), age range 25–45 years, were recruited from France, Northern Ireland, UK, Republic of Ireland, The Netherlands, and Spain, and their LDL composition and lag phase were measured. There were some differences in LDL carotenoid and α-tocopherol concentrations between countries. α-Tocopherol was low and β- + γ-tocopherol were high (P
ISSN:0007-1145
1475-2662
DOI:10.1079/BJN2001484