Combinatorial chemistry of beta-hairpins

Combinatorial chemistry is expanding rapidly both in terms of chemistry development and application to the synthesis of compound libraries for lead discovery and optimization. Combinatorial technologies continue evolving and developing, in fact they are being used as basic research tools in differen...

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Bibliographic Details
Published in:Molecular diversity 2003, Vol.6 (2), p.149-155
Main Authors: Pastor, M Teresa, Pérez-Payá, Enrique
Format: Article
Language:English
Subjects:
Combinatorial Chemistry Techniques - methods
Peptide Library
Peptides - chemical synthesis
Peptides - chemistry
Protein Structure, Secondary
Online Access:Get full text
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Summary:Combinatorial chemistry is expanding rapidly both in terms of chemistry development and application to the synthesis of compound libraries for lead discovery and optimization. Combinatorial technologies continue evolving and developing, in fact they are being used as basic research tools in different fields that include peptide/protein folding. This review examines the use of combinatorial chemistry in the design of peptides and protein domains that adopt beta-sheet conformations. In particular, the use of conformationally restricted peptide libraries has allowed the identification of linear peptides that are folded in a beta-hairpin structure in plain aqueous solutions.
ISSN:1381-1991
DOI:10.1023/B:MODI.0000006841.38638.c7