Design Considerations for Efficient and Effective Microarray Studies

This article describes the theoretical and practical issues in experimental design for gene expression microarrays. Specifically, this article 1) discusses the basic principles of design (randomization, replication, and blocking) as they pertain to microarrays, and 2) provides some general guideline...

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Bibliographic Details
Published in:Biometrics 2003-12, Vol.59 (4), p.822-828
Main Author: Kathleen Kerr, M.
Format: Article
Language:English
Subjects:
Biometrics
Biometry - methods
Block design
Composite sampling
Design
Design efficiency
Dyes
Experiment design
Experimental design
Gene expression
Genes
Humans
Microarray
Models, Genetic
Models, Statistical
Observer Variation
Oligonucleotide Array Sequence Analysis - methods
Population mean
Replication
Reproducibility of Results
Research Design
RNA
RNA - genetics
Statistical variance
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Summary:This article describes the theoretical and practical issues in experimental design for gene expression microarrays. Specifically, this article 1) discusses the basic principles of design (randomization, replication, and blocking) as they pertain to microarrays, and 2) provides some general guidelines for statisticians designing microarray studies.
ISSN:0006-341X
1541-0420
DOI:10.1111/j.0006-341X.2003.00096.x