Parenteral iron supplementation for the treatment of iron deficiency anemia in children

Iron-deficiency anemia impairs growth and intellectual development in children, which can be reversed only by early diagnosis and iron supplementation. Oral supplementation can efficiently replace stores, but in many cases parenteral iron is needed. Unfortunately some adverse reactions have limited...

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Bibliographic Details
Published in:Annals of hematology 2002-03, Vol.81 (3), p.154-157
Main Authors: SURICO, G, MUGGEO, P, MUGGEO, V, LUCARELLI, A, MARTUCCI, T, DANIELE, R. M, RIGILLO, N
Format: Article
Language:English
Subjects:
Anemia, Iron-Deficiency - blood
Anemia, Iron-Deficiency - drug therapy
Biological and medical sciences
Child
Child, Preschool
Female
General and cellular metabolism. Vitamins
Hemoglobins - analysis
Humans
Infant
Injections, Intramuscular
Injections, Intravenous
Iron - administration & dosage
Iron - therapeutic use
Male
Medical sciences
Pharmacology. Drug treatments
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Summary:Iron-deficiency anemia impairs growth and intellectual development in children, which can be reversed only by early diagnosis and iron supplementation. Oral supplementation can efficiently replace stores, but in many cases parenteral iron is needed. Unfortunately some adverse reactions have limited its use in children. We compared the efficacy and safety of intramuscular and intravenous administration in 33 evaluable children with severe iron deficiency and/or iron-deficiency anemia who failed to respond to oral iron supplementation. Nineteen children received intravenous infusion and 14 intramuscular injections. All children showed recovery from iron-deficiency anemia, with statistically similar improvement in hemoglobin levels. The duration of treatment was longer in those receiving intramuscular injection. Parenteral iron therapy for the treatment of iron-deficiency anemia is a rapid, easy, and definitive solution to a long-troubling situation. We suggest the use of parenteral iron, in particular intravenous iron, in children who do not recover from severe iron-deficiency anemia after oral therapy. We should consider the physical and neuropsychological sequelae of long-lasting iron deficiency in children and the fact that oral supplementation is less likely to replace iron stores.
ISSN:0939-5555
1432-0584
DOI:10.1007/s00277-001-0418-3