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Simultaneous analysis of γ-hydroxybutyric acid, γ-butyrolactone, and 1,4-butanediol by micellar electrokinetic chromatography
A micellar electrokinetic chromatography (MEKC) method was optimised for simultaneous analysis of γ-hydroxybutyric acid (GHB), γ-butyrolactone (GBL), and 1,4-butanediol (BD). Best conditions for separation and baseline stability were achieved using a carrier electrolyte comprising 30.0 mM sodium bar...
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| Published in: | Forensic science international 2002-02, Vol.125 (2), p.113-119 |
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| Language: | English |
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| container_title | Forensic science international |
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| creator | Dahlén, Johan Vriesman, Thyrsa |
| description | A micellar electrokinetic chromatography (MEKC) method was optimised for simultaneous analysis of γ-hydroxybutyric acid (GHB), γ-butyrolactone (GBL), and 1,4-butanediol (BD). Best conditions for separation and baseline stability were achieved using a carrier electrolyte comprising 30.0
mM sodium barbital and 150.0
mM sodium dodecyl sulphate (SDS) at pH 10.2. Calibration functions were linear, giving correlation coefficients (
r
2) >0.998 for the three target compounds. Limits of detection (LOD) defined as three times the noise, were 5.1
mg/l, 0.34 and 0.25
g/l for GHB, GBL and BD, respectively. The repeatability of migration times and peak areas, expressed as the R.S.D. (
n=9) was better than 0.41 and 3.05%, respectively. Some casework samples were analysed using the optimised conditions. |
| doi_str_mv | 10.1016/S0379-0738(02)00006-3 |
| format | article |
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mM sodium barbital and 150.0
mM sodium dodecyl sulphate (SDS) at pH 10.2. Calibration functions were linear, giving correlation coefficients (
r
2) >0.998 for the three target compounds. Limits of detection (LOD) defined as three times the noise, were 5.1
mg/l, 0.34 and 0.25
g/l for GHB, GBL and BD, respectively. The repeatability of migration times and peak areas, expressed as the R.S.D. (
n=9) was better than 0.41 and 3.05%, respectively. Some casework samples were analysed using the optimised conditions.</description><identifier>ISSN: 0379-0738</identifier><identifier>EISSN: 1872-6283</identifier><identifier>DOI: 10.1016/S0379-0738(02)00006-3</identifier><identifier>PMID: 11909651</identifier><identifier>CODEN: FSINDR</identifier><language>eng</language><publisher>Kidlington: Elsevier Ireland Ltd</publisher><subject>1,4-Butanediol ; 4-Butyrolactone - analysis ; Biological and medical sciences ; Butanediol ; Butylene Glycols - analysis ; Butyrolactone ; Calibration ; Capillary electrophoresis ; Chromatography ; Chromatography, Micellar Electrokinetic Capillary - methods ; Correlation coefficient ; Correlation coefficients ; Drug addictions ; Drugs ; Electrokinetics ; Electrolytes ; General aspects. Methods ; Hydroxybutyrates - analysis ; Medical sciences ; Micellar electrokinetic chromatography ; Sodium ; Sodium dodecyl sulfate ; Sodium lauryl sulfate ; Solvents ; Solvents - analysis ; Target detection ; Toxicology ; γ-Butyrolactone ; γ-Hydroxybutyric acid</subject><ispartof>Forensic science international, 2002-02, Vol.125 (2), p.113-119</ispartof><rights>2002 Elsevier Science Ireland Ltd</rights><rights>2002 INIST-CNRS</rights><rights>2002. Elsevier Science Ireland Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-90e6851ff6d72a8eaab9df8199c1c22b078e7dbbc7d4fadd0468a938bf66efe63</citedby><cites>FETCH-LOGICAL-c419t-90e6851ff6d72a8eaab9df8199c1c22b078e7dbbc7d4fadd0468a938bf66efe63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13576475$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11909651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dahlén, Johan</creatorcontrib><creatorcontrib>Vriesman, Thyrsa</creatorcontrib><title>Simultaneous analysis of γ-hydroxybutyric acid, γ-butyrolactone, and 1,4-butanediol by micellar electrokinetic chromatography</title><title>Forensic science international</title><addtitle>Forensic Sci Int</addtitle><description>A micellar electrokinetic chromatography (MEKC) method was optimised for simultaneous analysis of γ-hydroxybutyric acid (GHB), γ-butyrolactone (GBL), and 1,4-butanediol (BD). Best conditions for separation and baseline stability were achieved using a carrier electrolyte comprising 30.0
mM sodium barbital and 150.0
mM sodium dodecyl sulphate (SDS) at pH 10.2. Calibration functions were linear, giving correlation coefficients (
r
2) >0.998 for the three target compounds. Limits of detection (LOD) defined as three times the noise, were 5.1
mg/l, 0.34 and 0.25
g/l for GHB, GBL and BD, respectively. The repeatability of migration times and peak areas, expressed as the R.S.D. (
n=9) was better than 0.41 and 3.05%, respectively. Some casework samples were analysed using the optimised conditions.</description><subject>1,4-Butanediol</subject><subject>4-Butyrolactone - analysis</subject><subject>Biological and medical sciences</subject><subject>Butanediol</subject><subject>Butylene Glycols - analysis</subject><subject>Butyrolactone</subject><subject>Calibration</subject><subject>Capillary electrophoresis</subject><subject>Chromatography</subject><subject>Chromatography, Micellar Electrokinetic Capillary - methods</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>Drug addictions</subject><subject>Drugs</subject><subject>Electrokinetics</subject><subject>Electrolytes</subject><subject>General aspects. Methods</subject><subject>Hydroxybutyrates - analysis</subject><subject>Medical sciences</subject><subject>Micellar electrokinetic chromatography</subject><subject>Sodium</subject><subject>Sodium dodecyl sulfate</subject><subject>Sodium lauryl sulfate</subject><subject>Solvents</subject><subject>Solvents - analysis</subject><subject>Target detection</subject><subject>Toxicology</subject><subject>γ-Butyrolactone</subject><subject>γ-Hydroxybutyric acid</subject><issn>0379-0738</issn><issn>1872-6283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqFkcuK1EAUhgtRnHb0EZSAKAodrUtSl5XI4A0GXIyui5O62DUmqbYqEbPyoXwPn8nqdOOAG2tTcPj-n3P-H6GHBL8gmPCXV5gJVWPB5DNMn-PyeM1uoQ2RgtacSnYbbf4iZ-hezteFaVvK76IzQhRWvCUb9PMqDHM_wejinCsYoV9yyFX01e9f9W6xKf5YunlaUjAVmGC3h_k6iD2YKY5uW1S2ItvmMC4-NsS-6pZqCMb1PaTK9c5MKX4No5uKi9mlOMAUvyTY75b76I6HPrsHp_8cfX775tPF-_ry47sPF68va9MQNdUKOy5b4j23goJ0AJ2yXhKlDDGUdlhIJ2zXGWEbD9bihktQTHaec-cdZ-fo6dF3n-K32eVJDyGvC66Xa0Fa1lDeFPDxP-B1nFPJJWuqMCYYS6wK1R4pk2LOyXm9T2GAtGiC9aEfvfajD-FrTPXaj2ZF9-jkPneDszeqUyEFeHICIBvofYLRhHzDsVbwRrSFe3XkXAnte3BJZxPcaEr8qcStbQz_WeUPt86wnw</recordid><startdate>20020218</startdate><enddate>20020218</enddate><creator>Dahlén, Johan</creator><creator>Vriesman, Thyrsa</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20020218</creationdate><title>Simultaneous analysis of γ-hydroxybutyric acid, γ-butyrolactone, and 1,4-butanediol by micellar electrokinetic chromatography</title><author>Dahlén, Johan ; Vriesman, Thyrsa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-90e6851ff6d72a8eaab9df8199c1c22b078e7dbbc7d4fadd0468a938bf66efe63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>1,4-Butanediol</topic><topic>4-Butyrolactone - analysis</topic><topic>Biological and medical sciences</topic><topic>Butanediol</topic><topic>Butylene Glycols - analysis</topic><topic>Butyrolactone</topic><topic>Calibration</topic><topic>Capillary electrophoresis</topic><topic>Chromatography</topic><topic>Chromatography, Micellar Electrokinetic Capillary - methods</topic><topic>Correlation coefficient</topic><topic>Correlation coefficients</topic><topic>Drug addictions</topic><topic>Drugs</topic><topic>Electrokinetics</topic><topic>Electrolytes</topic><topic>General aspects. Methods</topic><topic>Hydroxybutyrates - analysis</topic><topic>Medical sciences</topic><topic>Micellar electrokinetic chromatography</topic><topic>Sodium</topic><topic>Sodium dodecyl sulfate</topic><topic>Sodium lauryl sulfate</topic><topic>Solvents</topic><topic>Solvents - analysis</topic><topic>Target detection</topic><topic>Toxicology</topic><topic>γ-Butyrolactone</topic><topic>γ-Hydroxybutyric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dahlén, Johan</creatorcontrib><creatorcontrib>Vriesman, Thyrsa</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Toxicology Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>ProQuest Biological Science Journals</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Forensic science international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dahlén, Johan</au><au>Vriesman, Thyrsa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous analysis of γ-hydroxybutyric acid, γ-butyrolactone, and 1,4-butanediol by micellar electrokinetic chromatography</atitle><jtitle>Forensic science international</jtitle><addtitle>Forensic Sci Int</addtitle><date>2002-02-18</date><risdate>2002</risdate><volume>125</volume><issue>2</issue><spage>113</spage><epage>119</epage><pages>113-119</pages><issn>0379-0738</issn><eissn>1872-6283</eissn><coden>FSINDR</coden><abstract>A micellar electrokinetic chromatography (MEKC) method was optimised for simultaneous analysis of γ-hydroxybutyric acid (GHB), γ-butyrolactone (GBL), and 1,4-butanediol (BD). Best conditions for separation and baseline stability were achieved using a carrier electrolyte comprising 30.0
mM sodium barbital and 150.0
mM sodium dodecyl sulphate (SDS) at pH 10.2. Calibration functions were linear, giving correlation coefficients (
r
2) >0.998 for the three target compounds. Limits of detection (LOD) defined as three times the noise, were 5.1
mg/l, 0.34 and 0.25
g/l for GHB, GBL and BD, respectively. The repeatability of migration times and peak areas, expressed as the R.S.D. (
n=9) was better than 0.41 and 3.05%, respectively. Some casework samples were analysed using the optimised conditions.</abstract><cop>Kidlington</cop><pub>Elsevier Ireland Ltd</pub><pmid>11909651</pmid><doi>10.1016/S0379-0738(02)00006-3</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0379-0738 |
| ispartof | Forensic science international, 2002-02, Vol.125 (2), p.113-119 |
| issn | 0379-0738 1872-6283 |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | 1,4-Butanediol 4-Butyrolactone - analysis Biological and medical sciences Butanediol Butylene Glycols - analysis Butyrolactone Calibration Capillary electrophoresis Chromatography Chromatography, Micellar Electrokinetic Capillary - methods Correlation coefficient Correlation coefficients Drug addictions Drugs Electrokinetics Electrolytes General aspects. Methods Hydroxybutyrates - analysis Medical sciences Micellar electrokinetic chromatography Sodium Sodium dodecyl sulfate Sodium lauryl sulfate Solvents Solvents - analysis Target detection Toxicology γ-Butyrolactone γ-Hydroxybutyric acid |
| title | Simultaneous analysis of γ-hydroxybutyric acid, γ-butyrolactone, and 1,4-butanediol by micellar electrokinetic chromatography |
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