The Age-Related Changes in the Incidence of `Natural' Anti-Sperm Antibodies Suggest they are not Auto-/Isoantibodies

PROBLEM: Establishing the age‐dependent patterns of sperm antibody levels among normal humans. METHODS OF STUDY: Sera samples from 498 healthy subjects aged 0–97 years – 246 males and 252 females – were tested by the gelatin agglutination test of Kibrick, tray agglutination test of Friberg, sperm im...

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Published in:American journal of reproductive immunology (1989) 2002-02, Vol.47 (2), p.65-71
Main Authors: KALAYDJIEV, SVETOSLAV K., DIMITROVA, DIMITRINA K., TRIFONOVA, NEDKA L., FICHOROVA, RAINA N., MASHAROVA, NATALIA G., RAICHEVA, YVETTE N., SIMEONOVA, MARIA N., TODOROVA, EVGENIA I., TODOROV, VELISLAV I., NAKOV, LYUDMIL S.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Aging
Aging - immunology
Antibodies - immunology
Autoantibodies - immunology
Biological and medical sciences
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
exogenous antigens
Female
Fundamental and applied biological sciences. Psychology
Humans
Infant
Infant, Newborn
Isoantibodies - immunology
Isoantigens - immunology
Male
Mammalian male genital system
Middle Aged
Morphology. Physiology
natural sperm antibodies
Spermatozoa - immunology
Vertebrates: reproduction
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Summary:PROBLEM: Establishing the age‐dependent patterns of sperm antibody levels among normal humans. METHODS OF STUDY: Sera samples from 498 healthy subjects aged 0–97 years – 246 males and 252 females – were tested by the gelatin agglutination test of Kibrick, tray agglutination test of Friberg, sperm immobilization test of Isojima and enzyme‐linked immunosorbent assay (ELISA). RESULTS: We found a significant increase in the level of sperm agglutinins after 40 years, which decreased after 88 years. The antibodies detected by ELISA were the highest among prepubertal subjects and also declined with aging. No age‐dependent changes were established for the sperm immobilizins. With few exceptions, there were no significant differences between male and female sera, as well as between sera of newborn and their mothers. CONCLUSIONS: These data are similar to those established for the age‐dependent changes of antibodies towards exogenous antigens, suggesting that the `naturally occurring' antibodies against human spermatozoa are not auto‐/isoantibodies.
ISSN:1046-7408
8755-8920
1600-0897
DOI:10.1034/j.1600-0897.2002.1o054.x