High concentrations of CA 125 in uterine flushings: influence of cause of infertility and menstrual cycle day

Uterine flushings were obtained under transvaginal ultrasonographic control from 132 women presenting for investigation and treatment of infertility. Levels of CA 125 were measured by radioimmunoassay and results expressed in relation to the total protein concentration of the same flushings. CA 125...

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Bibliographic Details
Published in:Gynecological endocrinology 2002-02, Vol.16 (1), p.19-25
Main Authors: HAMILTON, J. A, ILES, R. K, GUNN, L. K, WILSON, C. M. Y, LOWERS, A. M, GRUDZINSKAS, J. G
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Birth control
Body Fluids - chemistry
CA-125 Antigen - analysis
CA-125 Antigen - metabolism
Endometrium - pathology
Endometrium - secretion
Female
Female genital diseases
Follicular Phase
Gynecology. Andrology. Obstetrics
Humans
Infertility, Female - etiology
Infertility, Female - pathology
Medical sciences
Menstrual Cycle
Sterility. Assisted procreation
Tumors
Uterus - metabolism
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Summary:Uterine flushings were obtained under transvaginal ultrasonographic control from 132 women presenting for investigation and treatment of infertility. Levels of CA 125 were measured by radioimmunoassay and results expressed in relation to the total protein concentration of the same flushings. CA 125 was detected in uterine fluid at levels higher than those previously reported in peripheral blood. Uterine fluid CA 125 concentrations varied throughout the menstrual cycle, being highest in the mid-follicular phase (days 6 to 10). Uterine fluid CA 125 concentrations may reflect endometrial secretion of this protein more directly than serum levels. CA 125 concentrations did not vary according to the cause of infertility but further work in larger numbers of women is required.
ISSN:0951-3590
1473-0766
DOI:10.1080/713602992