ATPase pumps in osteoclasts and osteoblasts

Osteoblasts, osteocytes and osteoclasts are specialised cells of bone that play crucial roles in the formation, maintenance and resorption of bone matrix. Bone formation and resorption critically depend on optimal intracellular calcium and phosphate homeostasis and on the expression and activity of...

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Bibliographic Details
Published in:International Journal of Biochemistry and Cell Biology 2002-05, Vol.34 (5), p.459-476
Main Authors: Francis, Martin J.O, Lees, Rita L, Trujillo, Elisa, Martı́n-Vasallo, Pablo, Heersche, Johan N.M, Mobasheri, Ali
Format: Article
Language:English
Subjects:
Adenosine Triphosphatases - metabolism
adenosinetriphosphatase
Animals
Biological Transport - physiology
Bone
bone formation
bone resorption
Ca-ATPase
Gastric H,K-ATPase
Homeostasis
Humans
Ion Pumps - metabolism
Models, Biological
Na,K-ATPase
Osteoblast
osteoblasts
Osteoblasts - enzymology
Osteoblasts - metabolism
Osteoclast
osteoclasts
Osteoclasts - enzymology
Osteoclasts - metabolism
Osteocyte
plasma membrane
pumps
resorption
Vacuolar H-ATPase
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Summary:Osteoblasts, osteocytes and osteoclasts are specialised cells of bone that play crucial roles in the formation, maintenance and resorption of bone matrix. Bone formation and resorption critically depend on optimal intracellular calcium and phosphate homeostasis and on the expression and activity of plasma membrane transport systems in all three cell types. Osteotropic agents, mechanical stimulation and intracellular pH are important parameters that determine the fate of bone matrix and influence the activity, expression, regulation and cell surface abundance of plasma membrane transport systems. In this paper the role of ATPase pumps is reviewed in the context of their expression in bone cells, their contribution to ion homeostasis and their relation to other transport systems regulating bone turnover.
ISSN:1357-2725
1878-5875
DOI:10.1016/S1357-2725(01)00142-X