Residual goitre in the postiodization phase: iodine status, thiocyanate exposure and autoimmunity

Summary objective  This study was done to assess goitre prevalence, thyroid functional status and cause of residual goitre among school children in the postsalt iodization phase in India. design  A cross‐sectional study in which, 14 762 school children in the age group of 6–18 years, from different...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2003-12, Vol.59 (6), p.672-681
Main Authors: Marwaha, R. K., Tandon, Nikhil, Gupta, Nandita, Karak, A. K., Verma, K., Kochupillai, N.
Format: Article
Language:English
Subjects:
Adolescent
Age Distribution
Autoantibodies - blood
Biological and medical sciences
Causality
Child
Endocrinopathies
Epidemiologic Studies
Female
Fundamental and applied biological sciences. Psychology
Goiter - epidemiology
Goiter - immunology
Goiter - prevention & control
Humans
India - epidemiology
Iodine - administration & dosage
Iodine - urine
Male
Medical sciences
Microsomes - immunology
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Nutritional Status
Poverty
Sex Distribution
Sodium Chloride, Dietary - administration & dosage
Statistics, Nonparametric
Thiocyanates - urine
Thyroid Gland - immunology
Thyroid Gland - physiopathology
Thyroid. Thyroid axis (diseases)
Vertebrates: endocrinology
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Summary:Summary objective  This study was done to assess goitre prevalence, thyroid functional status and cause of residual goitre among school children in the postsalt iodization phase in India. design  A cross‐sectional study in which, 14 762 school children in the age group of 6–18 years, from different States and Union territories of India, were evaluated for goitre prevalence, urinary iodine and thiocyanate excretion, functional status of the thyroid as well as serological and cytopathological markers for thyroid autoimmunity. measurements  Urinary iodine (wet ashing method), urinary thiocyanate (colourimetric method), serum thyroxine [in‐house radioimmunoassay (RIA)], serum TSH (IRMA), antithyroid microsomal and antithyroglobulin antibodies (haemagglutination method) were estimated. Fine‐needle aspiration cytology was performed in all goitrous subjects giving consent. results  The overall goitre prevalence was 23% (27·1% girls; 17·8% boys, P 
ISSN:0300-0664
1365-2265
DOI:10.1046/j.1365-2265.2003.01895.x