The non-steroidal anti-inflammatory drug niflumic acid inhibits Candida albicans growth

The non-steroidal anti-inflammatory drug niflumic acid was found to inhibit growth of the yeast form of Candida albicans. Niflumic acid inhibited respiratory oxygen uptake and it is hypothesised that this was achieved by cytosolic acidification and block of glycolysis. Inhibitory concentrations are...

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Bibliographic Details
Published in:Mycopathologia (1975) 2002, Vol.153 (1), p.25-28
Main Authors: BAKER, Andrew, NORTHROP, Frederick D, MIEDEMA, Hendrik, DEVINE, Gary R, DAVIES, Julia M
Format: Article
Language:English
Subjects:
Acidification
Acids
Anti-inflammatory agents
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Antifungal Agents - pharmacology
Biological and medical sciences
Candida albicans - drug effects
Candida albicans - growth & development
Candida albicans - metabolism
Culture Media
Ethanol
Fundamental and applied biological sciences. Psychology
Glucose
Growth, nutrition, metabolism, transports, enzymes. Molecular biology
Microbiology
Mycology
Niflumic Acid - pharmacology
Oxygen Consumption - drug effects
Pathogenicity, host-agent relations, miscellaneous strains, epidemiology
Respiration
Yeast
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Summary:The non-steroidal anti-inflammatory drug niflumic acid was found to inhibit growth of the yeast form of Candida albicans. Niflumic acid inhibited respiratory oxygen uptake and it is hypothesised that this was achieved by cytosolic acidification and block of glycolysis. Inhibitory concentrations are compatible with current practice of topical application.
ISSN:0301-486X
1573-0832
DOI:10.1023/A:1015248027394