Integration of Emotion and Cognition in the Lateral Prefrontal Cortex

We used functional MRI to test the hypothesis that emotional states can selectively influence cognition-related neural activity in lateral prefrontal cortex (PFC), as evidence for an integration of emotion and cognition. Participants (n = 14) watched short videos intended to induce emotional states...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2002-03, Vol.99 (6), p.4115-4120
Main Authors: Gray, Jeremy R., Braver, Todd S., Raichle, Marcus E.
Format: Article
Language:English
Subjects:
Adult
Behavior - physiology
Biological Sciences
Brain
Cerebral hemispheres
Cognition
Cognition & reasoning
Cognition - physiology
Cognitive models
Crossovers
Emotion
Emotional states
Emotions
Emotions - physiology
Female
Functional Laterality - physiology
Humans
Language
Magnetic Resonance Imaging
Male
Memory - physiology
Mental stimulation
NMR
Nuclear magnetic resonance
Pattern Recognition, Visual - physiology
Photic Stimulation
Prefrontal Cortex - physiology
Psychology
Region of integration
Videotape Recording
Working memory
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Summary:We used functional MRI to test the hypothesis that emotional states can selectively influence cognition-related neural activity in lateral prefrontal cortex (PFC), as evidence for an integration of emotion and cognition. Participants (n = 14) watched short videos intended to induce emotional states (pleasant/approach related, unpleasant/withdrawal related, or neutral). After each video, the participants were scanned while performing a 3-back working memory task having either words or faces as stimuli. Task-related neural activity in bilateral PFC showed a predicted pattern: an Emotion × Stimulus crossover interaction, with no main effects, with activity predicting task performance. This highly specific result indicates that emotion and higher cognition can be truly integrated, i.e., at some point of processing, functional specialization is lost, and emotion and cognition conjointly and equally contribute to the control of thought and behavior. Other regions in lateral PFC showed hemispheric specialization for emotion and for stimuli separately, consistent with a hierarchical and hemisphere-based mechanism of integration.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.062381899