Sources of variation of Helicobacter pylori treatment success in adults worldwide: a meta-analysis

Background A vast number of Helicobacter pylori treatment trials have been conducted. Regimens may vary in efficacy in different patient populations. Methods We identified sources of treatment effect variation from 618 treatment groups using weighted cross-classified multi-level meta-regression mode...

Full description

Saved in:
Bibliographic Details
Published in:International journal of epidemiology 2002-02, Vol.31 (1), p.128-139
Main Authors: Fischbach, Lori A, Goodman, Karen J, Feldman, Mark, Aragaki, Corinne
Format: Article
Language:English
Subjects:
Adult
Anti-Bacterial Agents - therapeutic use
drug resistance
Drug Resistance, Microbial
Helicobacter Infections - drug therapy
Helicobacter pylori
Humans
meta-analysis
Metronidazole - therapeutic use
prevalence
Publication Bias
review
Treatment Outcome
treatments
world health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background A vast number of Helicobacter pylori treatment trials have been conducted. Regimens may vary in efficacy in different patient populations. Methods We identified sources of treatment effect variation from 618 treatment groups using weighted cross-classified multi-level meta-regression models. Summary effect estimates were calculated within groups that lacked identified heterogeneity. Results Overall, treatment was less successful with shorter treatment duration and dual drug (versus triple or quadruple drug) therapies. For nitroimidazole-based regimens, treatment was less successful in populations with frequent childhood H. pylori infection or metronidazole resistance and more successful in northeastern Asia. Non-nitroimidazole treatments of longer duration and those from less recent reports were most successful. Some one-week regimens—(nitroimidazole/ tetracycline/bismuth, ranitidine bismuth citrate/amoxicillin/clarithromycin, and clarithromycin/amoxicillin/proton pump inhibitor) were highly successful in northeastern Asia regardless of metronidazole resistance. The most successful regimen in populations with both a high prevalence of metrondiazole resistance and frequent infection in children (metronidazole/furazolidone/amoxicillin) eliminated fewer than 70% of infections. Conclusions More effective treatments are needed for most populations of the world where H. pylori infection in children and drug resistance are common. Current treatment guidelines do not coincide with the best treatment regimens identified in this meta-analysis.
ISSN:0300-5771
1464-3685
DOI:10.1093/ije/31.1.128