Coupling of theta activity and glucose metabolism in the human rostral anterior cingulate cortex: An EEG/PET study of normal and depressed subjects

In rodents, theta rhythm has been linked to the hippocampal formation, as well as other regions, including the anterior cingulate cortex (ACC). To test the role of the ACC in theta rhythm, concurrent measurements of brain electrical activity (EEG) and glucose metabolism (PET) were performed in 29 su...

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Bibliographic Details
Published in:Psychophysiology 2003-11, Vol.40 (6), p.939-949
Main Authors: Pizzagalli, Diego A., Oakes, Terrence R., Davidson, Richard J.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Anterior cingulate cortex
Behavioral psychophysiology
Biological and medical sciences
Brain Chemistry - physiology
Cerebral Cortex - diagnostic imaging
Cerebral Cortex - metabolism
Cerebral Cortex - physiology
Data Interpretation, Statistical
Depression
Depressive Disorder - diagnostic imaging
Depressive Disorder - metabolism
Depressive Disorder - physiopathology
Electroencephalogram
Electroencephalography
Electrophysiology
Female
Fluorodeoxyglucose F18
Fundamental and applied biological sciences. Psychology
Glucose - metabolism
Humans
Image Processing, Computer-Assisted
Limbic system
Male
Medical sciences
Mood disorders
Positron emission tomography
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychopathology. Psychiatry
Radiopharmaceuticals
Source localization
Theta Rhythm
Tomography, Emission-Computed
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Summary:In rodents, theta rhythm has been linked to the hippocampal formation, as well as other regions, including the anterior cingulate cortex (ACC). To test the role of the ACC in theta rhythm, concurrent measurements of brain electrical activity (EEG) and glucose metabolism (PET) were performed in 29 subjects at baseline. EEG data were analyzed with a source localization technique that enabled voxelwise correlations of EEG and PET data. For theta, but not other bands, the rostral ACC (Brodmann areas 24/32) was the largest cluster with positive correlations between current density and glucose metabolism. Positive correlations were also found in right fronto‐temporal regions. In control but not depressed subjects, theta within ACC and prefrontal/orbitofrontal regions was positively correlated. The results reveal a link between theta and cerebral metabolism in the ACC as well as disruption of functional connectivity within frontocingulate pathways in depression.
ISSN:0048-5772
1469-8986
1540-5958
DOI:10.1111/1469-8986.00112