An Association between Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis and Human Leukocyte Antigens

Purpose: Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE‐HS) is one of the medically intractable epilepsies that may be remediable with surgery. Although the pathogenesis of HS still remains obscure, genetics may play a role as a predisposing factor, with the genetically controlled im...

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Bibliographic Details
Published in:Epilepsia (Copenhagen) 2002-03, Vol.43 (3), p.236-239
Main Authors: Özkara, Çigdem, Altintas, Ayse, Yilmaz, Erkan, Eskazan, Esat, Erkol, Gökhan, Özyurt, Emin, Erdogan, Ergun, Kuday, Cengiz
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alleles
Biological and medical sciences
Child
Epilepsy, Temporal Lobe - immunology
Epilepsy, Temporal Lobe - pathology
Female
Genetics
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Hippocampal sclerosis
Hippocampus - pathology
HLA
HLA Antigens - analysis
HLA Antigens - genetics
HLA-DQ Antigens - analysis
HLA-DR4 Antigen - analysis
HLA-DR7 Antigen - analysis
Humans
Immunology
Male
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Neurology
Sclerosis
Temporal epilepsy
Tropical medicine
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Summary:Purpose: Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE‐HS) is one of the medically intractable epilepsies that may be remediable with surgery. Although the pathogenesis of HS still remains obscure, genetics may play a role as a predisposing factor, with the genetically controlled immune system as one of its aspects. Our aim in this study was to investigate whether there is any association between human leukocyte antigens (HLAs) that are related to chromosome 6 and this specific type of epilepsy. Methods: HLA class I and II typing were performed with the microlymphocytotoxicity method on 65 Turkish patients with MTLE‐HS and on 184 healthy controls. Results: Our study revealed a significantly high frequency of class II antigens HLA‐DQ2, ‐DR4, and ‐DR7 alleles and the combination of HLA‐DR4‐DQ2, and DR7‐DQ2 alleles. Conclusions: The HLA alleles that occur with increased frequency in many HLA‐ associated conditions appear to serve as risk factors that increase susceptibility but are not essential for disease expression. Our data support the role of genetic factors in the development of HS, possibly related to early childhood events that may act as a trigger factor to initiate the cascade in genetically prone patients with specific HLA types to give rise to MTLE eventually.
ISSN:0013-9580
1528-1167
DOI:10.1046/j.1528-1157.2002.13401.x