Pediatric celiac disease: clinicopathologic and genetic aspects

Evaluation for celiac disease (CD), an autoimmune enteropathy triggered by grain proteins in wheat, barley, rye, and possibly oats, is a common indication for pediatric endoscopy and biopsy. Duodenal or jejunal biopsy remains key for the initial diagnosis of CD. Small intestinal pathology may be dif...

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Bibliographic Details
Published in:Pediatric and developmental pathology 2003-11, Vol.6 (6), p.470-483
Main Authors: Lowichik, Amy, Book, Linda
Format: Article
Language:English
Subjects:
Biopsy
Celiac Disease
Child
Genetic Predisposition to Disease
HLA-DQ Antigens - genetics
Humans
Intestine, Small - pathology
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Description
Summary:Evaluation for celiac disease (CD), an autoimmune enteropathy triggered by grain proteins in wheat, barley, rye, and possibly oats, is a common indication for pediatric endoscopy and biopsy. Duodenal or jejunal biopsy remains key for the initial diagnosis of CD. Small intestinal pathology may be diffuse or focal in CD, and histologic findings are nonspecific and must be interpreted in conjunction with clinical and serologic findings. A standardized grading system for CD biopsies is recommended. This review article summarizes the epidemiology, clinical manifestations, genetics, pathogenesis, and serologic and histologic findings of CD. Clinical management of CD and general handling of small intestinal biopsies are also addressed.
ISSN:1093-5266
1615-5742
DOI:10.1007/s10024-002-2995-0