The effect of mid-luteal estradiol level on the outcome of ICSI-ET cycles

We investigated if mid-luteal estradiol levels could predict the outcome in intracytoplasmic sperm injection embryo transfer (ICSI-ET) cycles ( n=231). Pregnant and non-pregnant women were compared regarding their peak estradiol levels on human chorionic gonadotropin (hCG) injection day, and mid-lut...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2004-01, Vol.269 (2), p.134-138
Main Authors: Aktan, Erdal, Bozkurt, Kaan, Ozer, Dilek, Yucebilgin, Sait, Karadadas, Nedim, Bilgin, Onur
Format: Article
Language:English
Subjects:
Adult
Antiretroviral drugs
Biomarkers - blood
Embryo Transfer
Estradiol - blood
Female
Hormone replacement therapy
Humans
Luteal Phase - blood
Male
Predictive Value of Tests
Pregnancy
Pregnancy Rate
Sperm Injections, Intracytoplasmic
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Summary:We investigated if mid-luteal estradiol levels could predict the outcome in intracytoplasmic sperm injection embryo transfer (ICSI-ET) cycles ( n=231). Pregnant and non-pregnant women were compared regarding their peak estradiol levels on human chorionic gonadotropin (hCG) injection day, and mid-luteal estradiol levels on the 7th day following oocyte recovery. Pregnancy rates of the groups that were designed according to the "peak/mid-luteal estradiol level" and the mid-luteal estradiol levels were also compared. Peak and mid-luteal estradiol levels in pregnant women were higher than in non-pregnant women in all patients, although the difference between peak and mid-luteal estradiol levels were similar in pregnant and non-pregnants. Pregnant women had higher mid-luteal estradiol levels in good responders, but the peak estradiol levels of pregnant and non-pregnant women were similar. In poor responders, pregnant and non-pregnant women were similar with respect to peak and mid-luteal estradiol levels. Both in all patients and good responders, women with mid-luteal estradiol levels 2000 pg/ml. Peak/mid-luteal estradiol ratios of pregnant and non-pregnant women were not significantly different in all patients, good responders and poor responders; although a tendency for a lower ratio in pregnants was encountered in good responders. Pregnancy rates of the groups according to the "peak/mid-luteal estradiol ratio" were similar; in all patients, good responders and poor responders. A relation between the mid-luteal estradiol level and the outcome is encountered only in good responders.
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-003-0533-6