Enhancement of antibody response by one-trial conditioning: Contrasting results using different antigens

New research in conditioned enhancement of antibody response requires a general paradigm effective with different antigens. In this experiment series we applied a one-trial protocol using keyhole limpet hemocyanin immunization as an unconditioned stimulus. Several different conditions were tested. T...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2004, Vol.18 (1), p.76-80
Main Authors: Espinosa, Enrique, Calderas, Tania, Flores-Muciño, Óscar, Pérez-Garcı&#x0301, a, Georgina, Vázquez-Camacho, Ana C., Bermúdez-Rattoni, Federico
Format: Article
Language:English
Subjects:
Animals
Antibody Formation - immunology
Antibody response
Antigens - immunology
Conditioning (Psychology) - physiology
Dose-Response Relationship, Drug
Hemocyanins - immunology
Learning and memory
Male
Muramidase - immunology
Neuroimmunomodulation - physiology
One-trial conditioning
Psychoneuroimmunology
Random Allocation
Rat
Rats
Rats, Wistar
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Summary:New research in conditioned enhancement of antibody response requires a general paradigm effective with different antigens. In this experiment series we applied a one-trial protocol using keyhole limpet hemocyanin immunization as an unconditioned stimulus. Several different conditions were tested. Two different times between conditioning and test trial, two relevant antigen doses and the use of an antigen booster during test trial were investigated. We did not find a conditioned effect in any of the conditions used. In contrast, we found a reliable albeit modest conditioned effect using hen egg lysozyme as unconditioned stimulus. By comparing these and other findings we conclude that the number of conditioning trials is a possible requirement for a more reliable conditioning of antibody response.
ISSN:0889-1591
1090-2139
DOI:10.1016/S0889-1591(03)00108-9